RCT - Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy
NCT ID: NCT07335432
Last Updated: 2026-01-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
40 participants
INTERVENTIONAL
2024-09-01
2026-07-31
Brief Summary
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The primary outcome was to compare intraoperative blood loss between patients who received intravenous Vitamin C and those who did not, following an abdominal hysterectomy under general anesthesia.
Intraoperative estimated blood loss (EBL) was meticulously quantified by weighing surgical gauze and measuring suction canister volumes.
The secondary outcomes were to evaluate the potential benefits of Vitamin C administration, including:
* Reduction in the decline of hematocrit levels after surgery.
* Reduction of the length of hospital stay
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Experimental: Vitamin C
Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times.
Vitamin C (Ascorbic Acid)
Received two 1 gm doses of Vitamin C intravenously (IV).
first Dose: At midnight on the day of surgery.
Second Dose: Immediately after the surgical incision.
Placebo
Vitamin C (Ascorbic Acid)
Received two 1 gm doses of Vitamin C intravenously (IV).
first Dose: At midnight on the day of surgery.
Second Dose: Immediately after the surgical incision.
Interventions
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Vitamin C (Ascorbic Acid)
Received two 1 gm doses of Vitamin C intravenously (IV).
first Dose: At midnight on the day of surgery.
Second Dose: Immediately after the surgical incision.
Eligibility Criteria
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Inclusion Criteria
* No bleeding tendency.
* No history of anticoagulant or thrombolytic drug use
* No contraindications to vitamin C supplementation
Exclusion Criteria
* Underwent total abdominal hysterectomy due to gynecologic malignancy.
* Required emergency total abdominal hysterectomy.
* History of vitamin C supplementation within 2 weeks prior to surgery.
* History of smoking.
* Previous abdominal surgery, such as bowel surgery, cesarean section
20 Years
FEMALE
No
Sponsors
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Queen Savang Vadhana Memorial Hospital, Thailand
OTHER
Responsible Party
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Aektanat Tawornkitpanich
M.D.
Locations
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Queen Savang Vadhana Memorial hospital
Si Racha, Changwat Chon Buri, Thailand
Countries
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Other Identifiers
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012/2567
Identifier Type: -
Identifier Source: org_study_id
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