Intravenous Ascorbic Acid Administration in Hysterectomy

NCT ID: NCT03965637

Last Updated: 2020-05-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-23

Study Completion Date

2020-01-30

Brief Summary

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vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water\_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

Detailed Description

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In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.

Conditions

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Abdominal Hysterectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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vitamin C

Intervention patients will be received double dose of Ascorbic acid via intravenous injection

Group Type EXPERIMENTAL

vitamin C

Intervention Type DRUG

water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection

Control

Control patients will not be received any intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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vitamin C

water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection

Intervention Type DRUG

Other Intervention Names

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ascorbic acid

Eligibility Criteria

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Inclusion Criteria

* To be 18 years and older
* No smoking
* No history of bleeding disorder
* No history of favism
* No history of uterus, ovary, cervical cancer

Exclusion Criteria

* Need to injection of vasopressor drugs
* Surgeon disagreement
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Shahid Beheshti University

OTHER

Sponsor Role lead

Responsible Party

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Zahra Vahdat Shariatpanahi

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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zahra vahdat shariatpanahi, MD,PhD

Role: STUDY_CHAIR

Associatec professor

Locations

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Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences

Tehran, , Iran

Site Status

Countries

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Iran

References

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Farahani-Jam S, Yaghmaei M, Vahdat Shariatpanahi Z. Effect of intravenous ascorbic acid administration on hemorrhage and wound complications in total abdominal hysterectomy: A prospective randomized clinical trial. Clin Nutr ESPEN. 2022 Jun;49:74-78. doi: 10.1016/j.clnesp.2022.03.024. Epub 2022 Mar 26.

Reference Type DERIVED
PMID: 35623878 (View on PubMed)

Other Identifiers

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17912

Identifier Type: -

Identifier Source: org_study_id

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