Apparent Diffusion Coefficient of the Intervertebral Disc in Children: Pilot Study
NCT ID: NCT07331298
Last Updated: 2026-01-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
60 participants
OBSERVATIONAL
2026-01-05
2028-04-01
Brief Summary
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Current knowledge is limited as to its origin on the one hand and the evolutionary nature of scoliosis on the other.
The mechanical parameters of the intervertebral disc are incompletely known from the deep location of this organ, its fragile nature in vivo and its susceptibility to desiccation during ex-vivo analysis.
To complete our knowledge of the mechanical parameters of the intervertebral disc of scoliotic and non-scoliotic children, we are proposing an in vivo, non-invasive and non-irradiating study carried out in children who are the main target of this pathology.
The objective of this work is to characterize the diffusion parameters (apparent diffusion coefficient ADC) of the intervertebral disc in vivo, in a non-invasive and non-irradiating manner by magnetic resonance imaging in children and adolescents. As this measurement has not been carried out in children and adolescents, we want to perform these MRI scans in children free from scoliosis and carriers of scoliosis.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Scoliotic patients
children with spinal deformity characterized by a hump on clinical examination and a radiological deformation in the coronal plane greater than 10 ° .
magnetic resonance imaging of the lumbar or spinal region
The duration of the acquisition sequence between 2 and 10 minutes additional compared to a conventional magnetic resonance imaging examination.
Non scoliotic patients
Childrne with no hump on clinical examination, able to walk.
magnetic resonance imaging of the lumbar or spinal region
The duration of the acquisition sequence between 2 and 10 minutes additional compared to a conventional magnetic resonance imaging examination.
Interventions
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magnetic resonance imaging of the lumbar or spinal region
The duration of the acquisition sequence between 2 and 10 minutes additional compared to a conventional magnetic resonance imaging examination.
Eligibility Criteria
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Inclusion Criteria
* Children undergoing magnetic resonance imaging of the lumbar or spinal region as part of their routine care
* Scoliotic: spinal deformity characterized by a hump on clinical examination and a radiological deformation in the coronal plane greater than 10 ° with no etiology found (idiopathic)
* Healthy: no hump on clinical examination, walking patients (level 1 and 2 of the global motor function classification system)
Exclusion Criteria
* behavioral disturbances incompatible with the performance of the magnetic resonance imaging examination.
* Refusal of participation.
* Thoracic scoliosis
8 Years
16 Years
ALL
No
Sponsors
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University Hospital, Limoges
OTHER
Responsible Party
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Locations
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Limoges University Hospital
Limoges, , France
Toulouse University Hospital
Toulouse, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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87RI19_0004 (CADDIE)
Identifier Type: -
Identifier Source: org_study_id
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