Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

49 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-05

Study Completion Date

2022-04-30

Brief Summary

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Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.

The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.

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Detailed Description

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Conditions

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Healthy Volunteer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Spinal cord Tractography

Healthy volunteer having the tractography exam

Group Type EXPERIMENTAL

Spinal cord Tractography in order to differentiate spinal tracts.

Intervention Type PROCEDURE

Spinal cord tractography using DTI MRI sequences of the brain and spinal cord, in order to differentiate tracts at the spinal cord level; and by performing a stitching process between Brain and Spinal cord DTI sequences.

Interventions

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Spinal cord Tractography in order to differentiate spinal tracts.

Spinal cord tractography using DTI MRI sequences of the brain and spinal cord, in order to differentiate tracts at the spinal cord level; and by performing a stitching process between Brain and Spinal cord DTI sequences.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patient\> 18 years old
* Healthy volunteer
* Social insured in France
* Patient who signed the informed consent of the study

Exclusion Criteria

* Medical or surgical history of disease that may affect the central nervous system, or the spine
* History of spine or spinal cord trauma.
* Spinal osteoarthritis which can lead to a medullary hyper signal.
* Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc.
* Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice).
* Pregnant and / or breastfeeding woman.

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes