Predictors of Myasthenia Gravis Outcome Following Thoracoscopic Thymectomy: Comparative Study Between Thymomatous and Non-Thymomatous Patients

NCT ID: NCT07319689

Last Updated: 2026-01-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-01-01
• Study Completion Date: 2025-12-18

Brief Summary

This study aimed to assess and compare predictors of outcome in patients with thymomatous and non-thymomatous MG undergoing Thoracoscopic thymectomy.

Detailed Description

Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder characterized by fluctuating muscle weakness resulting from antibodies that target acetylcholine receptors or associated proteins at the neuromuscular junction.

Thoracoscopic thymectomy becomes more prominent than traditional transsternal thymectomy due to fewer perioperative complications with shorter hospital stays and more favorable long-term outcomes.

Prognostic outcomes following thoracoscopic thymectomy can vary significantly between non-thymomatous and thymomatous MG, necessitating a thorough investigation of these differences.

Conditions

Predictor; Myasthenia Gravis; Thoracoscopic Thymectomy; Thymomatous; Non-Thymomatous

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Thymomatous Myasthenia Gravis group

Thymomatous myasthenia gravis (patients with histologically confirmed thymoma).

Data collection

Intervention Type: OTHER

Data were obtained from patient files, operative notes, and electronic medical records.

Non-thymomatous Myasthenia Gravis group

Non-thymomatous myasthenia gravis (patients with thymic hyperplasia or normal/ involuted thymus).

Data collection

Intervention Type: OTHER

Data were obtained from patient files, operative notes, and electronic medical records.

Interventions

Data collection

Data were obtained from patient files, operative notes, and electronic medical records.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Both sexes.
• Confirmed diagnosis of Myasthenia Gravis (MG).
• Underwent Thoracoscopic thymectomy.
• Availability of complete preoperative and postoperative records, including imaging and histopathology.
• Minimum follow-up of 9 months post-surgery.

Exclusion Criteria

• Patients who underwent thymectomy for indications other than MG.
• Incomplete medical records or loss to follow-up before outcome assessment.
• Patients with concomitant neuromuscular disorders other than MG

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tanta University

OTHER

Sponsor Role: lead

Responsible Party

Mostafa Mohamed Elawady

Lecturer of Neuropsychiatry, Tanta University, Tanta, Egypt.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Tanta University

Tanta, El-Gharbia, Egypt

Countries

Egypt

Other Identifiers

36264PR13103/10/25

Identifier Type: -

Identifier Source: org_study_id