Predictive Factors for Medullary Thyroid Cancer Aggressiveness

NCT ID: NCT06292988

Last Updated: 2025-01-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-01

Study Completion Date

2024-04-15

Brief Summary

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This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.

Detailed Description

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This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients \>18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.

Conditions

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Medullary Thyroid Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Total Thyroidectomy

Total thyroidectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection

Exclusion Criteria

* Age \< 18 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aristotle University Of Thessaloniki

OTHER

Sponsor Role lead

Responsible Party

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Papavramidis Theodossis

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Theodossis Papavramidis, Prof

Role: PRINCIPAL_INVESTIGATOR

1st Propedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Greece

Locations

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Oregon Health & Science University, Oregon

Oregon City, Oregon, United States

Site Status

Department of Surgery, Saint John of God Hospital, Salzburg, Austria

Salzburg, , Austria

Site Status

Saint Luc, University Clouvain, Belgium

Brussels, , Belgium

Site Status

Head and Neck Surgery Department, Hospital Ana Nery, Santa Cruz do Sul, Brazil

Santa Cruz do Sul, , Brazil

Site Status

University Clinic of Surgery, University Hospital "Lozenec"

Sofia, , Bulgaria

Site Status

Chinese University of Hong Kong

Hong Kong, , China

Site Status

Head and Neck Department Oncologos del Occidente, Universidad de Caldas, Manizales, Colombia

Manizales, , Colombia

Site Status

the University Hospital Center Sestre milosrdnice, Zagreb, Croatia, Department of Otorhinolaryngology and Head and Neck Surgery

Zagreb, , Croatia

Site Status

Head and Neck Surgery, Brest University Hospital, Brest, France

Brest, , France

Site Status

The University Hospital of Poitiers, France

Poitiers, , France

Site Status

Thyroid Surgery Clinic IKE, Athens, Greece

Athens, , Greece

Site Status

ENT Department University Hospital of Larissa

Larissa, , Greece

Site Status

Department of Surgery, General University Hospital of Patras

Pátrai, , Greece

Site Status

Aristotle University of Thessaloniki

Thessaloniki, , Greece

Site Status

Gennimatas General Hospital

Thessaloniki, , Greece

Site Status

Department of ENT-Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar

Bhubaneswar, , India

Site Status

KMCH and KMCH Comprehensive Cancer Center

Coimbatore, , India

Site Status

Department of Endocrine and Breast Surgery at Sanjay Gandhi Post Graduate Institute of Medical Sciences

Madurai, , India

Site Status

Department of Surgery, Maulana Azad Medical College & Lok Nayak Hospital

New Delhi, , India

Site Status

Endocrine and Metabolic Surgery, Bhargav Endocrine Hospital, Vijayawada, India

Vijayawada, , India

Site Status

University of Sulaimani | UNIVSUL ,Department of Surgery, Kurdistan

Erbil, , Iraq

Site Status

ASL VCO - San Biagio Hospital - Domodossola (VB) - Italy

Domodossola, , Italy

Site Status

Dipartimento di Scienze Chirurgiche (DISC), University of Genoa, Italy

Genoa, , Italy

Site Status

Asst Santi Paolo e Carlo - Ospedale Polo Universitario San Paolo, Milan, Italy

Milan, , Italy

Site Status

UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario A Gemelli IRCCS

Roma, , Italy

Site Status

Department of Medical and Surgical Sciences, University of Trieste, Cattinara Teaching Hospital, Trieste, Italy

Trieste, , Italy

Site Status

Department of Surgery and Oncology, Endocrine Surgery Unit, Verona University Hospital

Verona, , Italy

Site Status

Hashemite University of Zarqa

Zarqa, , Jordan

Site Status

Hepatobiliairy and endocrine surgery, Ibn Sina Hospital, Medical School of Medecine Rabat, Mohamed Vth University of Rabat Morocco

Marrakesh, , Morocco

Site Status

Division of General, Endocrine and Transplant Surgery, Medical University of Gdańsk

Gdansk, , Poland

Site Status

Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Medical School, University of Belgrade

Belgrade, , Serbia

Site Status

Comenius University in Bratislava, Department of Paediatric Surgery, National Institute of Children's Diseases

Bratislava, , Slovakia

Site Status

Department of oncological surgery, St. Elisabeth cancer Institute

Bratislava, , Slovakia

Site Status

Hospital Clinic (Barcelona, Spain)

Barcelona, , Spain

Site Status

Universitaria de Cordoba

Córdoba, , Spain

Site Status

Hospital Regional de Málaga

Málaga, , Spain

Site Status

Department of General and Digestive Surgery, Division of Endocrine Surgery, Complexo Hospitalario Universitario de Vigo, Vigo, Spain

Vigo, , Spain

Site Status

Bern University Hospital

Bern, , Switzerland

Site Status

Geneva University Hospital

Geneva, , Switzerland

Site Status

Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok, Thailand

Bangkok, , Thailand

Site Status

Ankara University Faculty of Medicine, Department of Endocrine Surgery

Ankara, , Turkey (Türkiye)

Site Status

Acibadem MAA University

Istanbul, , Turkey (Türkiye)

Site Status

Cerrahpasa medical faculty endocrine surgery department

Istanbul, , Turkey (Türkiye)

Site Status

Department of Endocrin Pathology Unit, University of Health Sciences, Faculty of Medicine, Bakırköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey

Istanbul, , Turkey (Türkiye)

Site Status

Endocrine surgeon-consultant, International medical center "CITIDOCTOR"

Kyiv, , Ukraine

Site Status

Department of Radiology, Thien Hanh Hospital, Buon Ma Thuot, Vietnam

Việt Trì, , Vietnam

Site Status

Countries

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United States Austria Belgium Brazil Bulgaria China Colombia Croatia France Greece India Iraq Italy Jordan Morocco Poland Serbia Slovakia Spain Switzerland Thailand Turkey (Türkiye) Ukraine Vietnam

Other Identifiers

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MYELO

Identifier Type: -

Identifier Source: org_study_id

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