The Use of Rhythmic Light Therapy in Mild Cognitive Impairment

NCT ID: NCT07318038

Last Updated: 2026-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-08

Study Completion Date

2026-06-30

Brief Summary

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In this within-subjects, crossover study, participants will undergo Electroencephalogram (EEG) recordings before, during, and after each of three 1-hour sessions. All participants will experience all three conditions: (1) dual-frequency visual (10 and 40 Hz), (2) single-frequency visual (40 Hz), and (3) non-rhythmic stimulation. EEG spectral power and amplitude coupling will be analyzed to determine whether stimulation-induced increases in alpha-gamma neural synchrony translate to improvements in cognitive performance.

Detailed Description

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Conditions

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Mild Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Dual frequency flickering light

Light flickering with 10 Hz + 40 Hz visual stimulation

Group Type EXPERIMENTAL

Flickering Light

Intervention Type DEVICE

Red Flickering Light programed to three different visual stimulations

Single frequency flickering light

Light flickering with 10 Hz visual stimulation

Group Type EXPERIMENTAL

Flickering Light

Intervention Type DEVICE

Red Flickering Light programed to three different visual stimulations

non-rhythmic flickering light

Light flickering with random visual stimulation

Group Type PLACEBO_COMPARATOR

Flickering Light

Intervention Type DEVICE

Red Flickering Light programed to three different visual stimulations

Interventions

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Flickering Light

Red Flickering Light programed to three different visual stimulations

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* History of Mild Cognitive Impairment with a Montreal Cognitive Assessment score between 18 and 25

Exclusion Criteria

* History of epilepsy or photosensitivity
* Blindness or other obstructive vision conditions
* retinal diseases
* presence of another brain disease accounting for their cognitive status
Minimum Eligible Age

55 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Icahn School of Medicine at Mount Sinai

OTHER

Sponsor Role lead

Responsible Party

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Mariana Figueiro

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mariana Figueiro, PhD

Role: PRINCIPAL_INVESTIGATOR

Icahn School of Medicine at Mount Sinai

Locations

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Icahn School of Medicine at Mount Sinai

New York, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Barbara Plitnick

Role: CONTACT

518-242-4603

Facility Contacts

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Barbara Plitnick

Role: primary

518-242-4603

Other Identifiers

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STUDY-25-01233

Identifier Type: -

Identifier Source: org_study_id

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