Adrenaline V/s Dopamine in Fuid Refractory Septic Shock

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-01

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children. The efficacy will be checked based on heart rate , GCS, capillary refill time , palpable pripheral pulse , urine output and systolic blood pressure.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Outcome of Using Hydrocortisone in Early Treatment of Pediatric Septic Shock

NCT07313670

Septic Shock

NOT_YET_RECRUITING NA

Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography

NCT07136532

Septic Shock Echocardiography Guided Fluid Management

RECRUITING

Lactate Kinetics in Septic Shock

NCT05349370

Sepsis Septic Shock

RECRUITING NA

Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock

NCT01310790

Shock, Septic

COMPLETED PHASE4

The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock

NCT05402553

Sepsis Septic Shock

UNKNOWN PHASE1/PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a randomized control trial in which children / patients diagnosed with Fluid refractory Septic shock will be provided with one of the two drugs ina randomzied way and their efficacy will be assesed on the basis of correction of various parameters at various points of time.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Fluid Refractory Septic Shock Septic Shock

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group A

These patients will receive 0.1-0.3ug/kg/min of adrenaline when diagnosed with fluid refractory Septic shock .

Group Type EXPERIMENTAL

Adrenaline

Intervention Type DRUG

The adrenaline will be given as a vasoconstrictor in the dose of 0.1-0.3ug/kg/min to the patients in group A when diagnosed with fluid refractory septic shock

Group B

The patients in this arm of study will be provided with dopamine 10-20ug/kg/min when diagnosed with fluid refractory septic shock.

Group Type ACTIVE_COMPARATOR

Dopamine

Intervention Type DRUG

The drug dopamine will be adminitered in dose of 10-20ug/kg/min to the patients of group B when diagnosed with fluid refractory septic shock.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Adrenaline

The adrenaline will be given as a vasoconstrictor in the dose of 0.1-0.3ug/kg/min to the patients in group A when diagnosed with fluid refractory septic shock

Intervention Type DRUG

Dopamine

The drug dopamine will be adminitered in dose of 10-20ug/kg/min to the patients of group B when diagnosed with fluid refractory septic shock.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition.

\-

Exclusion Criteria

* Patients with

1. cardiopumonary Bypass during last 5 days
2. Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease
3. neuromuscular discorder
4. Metabolic disorders
5. Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation

Minimum Eligible Age

1 Month

Maximum Eligible Age

12 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No