MedDataX Logo

Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study

NCT ID: NCT07267767

Last Updated: 2025-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

3500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-04-10

Study Completion Date

2024-06-20

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study. Cohort 1 served primarily as the training and internal validation set, while Cohort 2 was used for external validation of the predictive model constructed from Cohort 1. We used six distinct machine learning methodss, including DT, RF, XGBOOST, SVM, lightGBM, and SHLNN, in addition to conventional logistic regression to create the predictive model. We chose the approach with the best sensitivity and specificity by comparing the concordance index(C-index) akin to the area under the ROC curve (AUC) of these seven distinct model-building methods. The predictive model for Cohort 1 was then built using this method, and internal validation was finished. Lastly, Cohort 2 underwent external validation of the predictive model

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Evaluation of AL Prediction for Rectal Cancer

NCT05610904

Anastomotic Leak Rectum
UNKNOWN NA

A Prediction Model of Anastomotic Stricture After Rectal Cancer

NCT06404554

Colorectal Cancer Rectal Cancer Anastomotic Stenosis
COMPLETED

Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation

NCT06814093

Rectal Cancer
ACTIVE_NOT_RECRUITING

Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome

NCT07041515

Rectal Neoplasm
NOT_YET_RECRUITING NA

International Low Anterior Resection Score Evaluation

NCT04040842

Low Anterior Resection Syndrome
RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Rectal Cancer LARS - Low Anterior Resection Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

nCRT

neoadjuvant chemoradiotherapy

Intervention Type PROCEDURE

BMI

Body Mass Index

Intervention Type BEHAVIORAL

Distance from AV

Distance from AV

Intervention Type DIAGNOSTIC_TEST

Surgical type

laparoscopic and robotic surgery

Intervention Type PROCEDURE

Surgical approach

tatme + isr

Intervention Type PROCEDURE

LCA Preserving

LCA Preserving

Intervention Type PROCEDURE

Prophylactic stoma

Prophylactic stoma

Intervention Type PROCEDURE

Anastomotic leakage

Anastomotic leakage

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

\-

Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

China-Japan Union Hospital, Jilin University

OTHER

Sponsor Role collaborator

Northern Jiangsu People's Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Daorong Wang

NANJING UNIVERSITY

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

jiangsuNorthen20

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
NCT06914245 RECRUITING NA
Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome.
NCT06628674 RECRUITING NA
Comparison of Short- and Long-term Outcomes Between Robotic and Laparoscopic Hemicolectomy of Right Colon Cancer : A Multicenter Propensity Score Matching Analysis
NCT07029464 NOT_YET_RECRUITING
Study on Effect of Robotic Versus Laparoscopic Surgical Technology on Genitourinary Function After Total Mesorectal Excision for Rectal Cancer
NCT06409403 RECRUITING NA
Safety and Efficacy of Reduced-port Laparoscopic Surgery for Patients Of Colon and Upper Rectal Cancer
NCT05953662 ACTIVE_NOT_RECRUITING NA
Robotic Assisted Transanal Total Mesorectal Excision Surgery for Rectal Cancer in Low Site
NCT03422835 UNKNOWN PHASE2
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome
NCT04023448 UNKNOWN NA
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer
NCT05943444 RECRUITING NA
Oncological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer.
NCT05201885 RECRUITING
Robotic Versus Laparoscopic Low Anterior Resection for Rectal Cancer
NCT03209076 UNKNOWN NA
Comparison of Short-term Outcomes of Robotic and Laparoscopic Surgery in Patients With Different Body Mass Index for Mid and Low Rectal Cancer
NCT06396975 COMPLETED
Robotic-Assisted or Laparoscopic Radical Resection for Rectal Cancer With or Without Left Colic Artery Preservation
NCT06376227 COMPLETED
Comparison of Robotic Versus Laparoscopic Surgery for Visceral Obesity in Mid-Low Rectal Cancer: A Propensity-Matched Analysis
NCT06397053 COMPLETED
Complete Versus Partial Preservation of Denonvilliers' Fascia on Urogenital Function in Locally Advanced Rectal Cancer
NCT04672603 UNKNOWN NA
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
NCT07346534 ENROLLING_BY_INVITATION NA
Comparison of NOSES and Conventional Laparoscopic Surgery in Colorectal Cancer
NCT04559087 UNKNOWN NA
The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer.
NCT05445245 COMPLETED
The Clinical Study of Making the Evidence With Application of Da Vinci-Robot Assisted Low Anterior Resection in Rectal Cancer
NCT01125111 COMPLETED
Multiple Firings in Double-stapled Colorectal Anastomosis
NCT05498506 COMPLETED
Bacteriological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer.
NCT05201872 UNKNOWN
The Comparison Between Traditional Laparoscopy-assisted Surgery and NOSES in Radical Resection of Colorectal Cancer
NCT03470142 UNKNOWN NA
ERAS in Elderly Colorectal Cancer Surgery
NCT06764888 COMPLETED
J-Pouch vs Side-to-End Anastomosis After Hand-Assisted Laparoscopic Low Anterior Resection for Rectal Cancer
NCT02627729 COMPLETED NA
Robotic Assisted Colon and Rectal Surgery Prognostic and Outcome Analysis
NCT05210647 COMPLETED
Comparison of Laparoscopic and Open Surgery for Colorectal Malignancy in Obese Patients
NCT06221878 COMPLETED