Multimodal Prediction of Response to Chemoradiotherapy for Squamous Cell Carcinoma of the Head and Neck
NCT ID: NCT07259915
Last Updated: 2025-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
152 participants
INTERVENTIONAL
2025-12-01
2030-08-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Multimodal approach
The patient will undergo multimodal imaging and biological sampling
Multimodal approach
The patient will undergo MRI, PET/can and biological samples
Interventions
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Multimodal approach
The patient will undergo MRI, PET/can and biological samples
Eligibility Criteria
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Inclusion Criteria
* With lymph node involvement (cN1, cN2, or cN3) (confirmation of lymph node involvement after review of imaging in CCP and without histological confirmation required)
* Eligible for curative treatment with cisplatin-based chemoradiotherapy alone (100 mg/m2 every 3 weeks or 40 mg/m2 weekly)
* Regardless of p16 status
* Affiliated with or covered by a social security system
Exclusion Criteria
* Primary squamous cell carcinoma of the lymph nodes
* History of radiotherapy to the head and neck region
* Radiochemotherapy not based on the use of cisplatin
* Pregnant or breastfeeding women
* History of invasive cancer in the last 3 years (except for Breslow melanoma less than 1 mm)
* Contraindication to MRI, CT, or PET/CT
* Allergy or contraindication to iodine, gadolinium, or 18F-FDG
* Uncontrolled diabetes (fasting blood glucose greater than 12 mmol/l)
* Patients unable to understand the study for any reason or to comply with the trial requirements (language, psychological, geographical issues, etc.)
* Patients under guardianship or conservatorship
* Patients deprived of their liberty by judicial or administrative decision
* Patients undergoing psychiatric care that renders them incapable of giving their consent
* Patients admitted to a health or social care facility for purposes other than research
18 Years
ALL
No
Sponsors
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Centre Henri Becquerel
OTHER
Responsible Party
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Locations
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Centre Henri Becquerel
Rouen, , France
Centre Hospitalier Universitaire
Rouen, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CHB24.04
Identifier Type: -
Identifier Source: org_study_id
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