Time to Treatment and Disease-free Survival of Patients With High-risk Head-neck Cutaneous Squamous Cell Carcinoma
NCT ID: NCT05845632
Last Updated: 2023-08-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
965 participants
OBSERVATIONAL
2022-01-01
2023-10-01
Brief Summary
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Detailed Description
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Risk of metastasis and recurrence in general cSCCs are 2.6-5% and 1.9-3.7%, respectively. However, these risk ratios may increase to 37% in high-risk cSCCs. High risk cSCCs are defined as cSCCs with risk factors for development of metastatic disease or recurrence, e.g. poor histological differentiation, perineural/lymphovascular infiltration, diameter ≥20 mm.
Due to the increasing incidence, advanced age, risk of metastasis and recurrence, and the high risk-location in the head-neck region related to functional and cosmetic importance, high-risk cSCCs in the head-neck region (high-risk HNcSCCs) require complex and multidisciplinary care. Therefore, care pathways have been developed. An important part of these care pathways are waiting times and, in particular, the time to treatment. For example, in mucosal head-neck tumors, prolonged waiting times have been described to be associated with reduced survival rates. This led to the hypothesis that prolonged waiting times result result in lower survival rates for patients with high-risk HNcSCCs. This study aimed to investigate the association between time to treatment defined as date of pathological diagnosis to date of start treatment) and disease free survival in patients with high risk HNcSCCs.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Short time to treatment (<30 days)
Patients with high-risk HNcSCC with a time to treatment (date of pathological diagnosis to date of start treatment) of less than 30 days.
Treatment
Patients were treated with surgery, radiotherapy or surgery with postoperative radiotherapy.
Long time to treatment (30 days or more)
Patients with high-risk HNcSCC with a time to treatment (date of pathological diagnosis to date of start treatment) of 30 days or more.
Treatment
Patients were treated with surgery, radiotherapy or surgery with postoperative radiotherapy.
Interventions
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Treatment
Patients were treated with surgery, radiotherapy or surgery with postoperative radiotherapy.
Eligibility Criteria
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Inclusion Criteria
* Treated in the Maastricht University Medical Center+ (MUMC+) or Radboud University Medical Center (RadboudUMC)
* Treated between 2010 to 2018
Exclusion Criteria
* Patients with a T1 HNcSCC
* Patients with recurrence or metastatic disease of a previously treated HNcSCC
18 Years
ALL
No
Sponsors
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Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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N Kelleners-Smeets, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Maastricht University Medical Center
Locations
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Maastricht University Medical Center+
Maastricht, , Netherlands
Radboud University Medical Center
Nijmegen, , Netherlands
Countries
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References
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Related Links
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Integral cancer center Netherlands; incidence rates on cutaneous squamous cell carcinomas
Other Identifiers
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2021-2885-A-2
Identifier Type: -
Identifier Source: org_study_id
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