Clinico-Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate .

NCT ID: NCT07259863

Last Updated: 2025-12-02

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 35 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-12-01
• Study Completion Date: 2026-11-30

Brief Summary

1. Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia.

2. Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.

Detailed Description

Aplastic anaemia is a term describing the common findings of pancytopenia and marrow hypoplasia from arising variety of disease states, including acquired aplastic anaemia and a variety of congenital marrow failure states(1). The global incidence of paediatric AA varies geographically, with rates of 2 to 3 cases per million per year in Europe, but higher in East Asia and certain developing regions(2) .Among Egyptian Children, inherited bone marrow failure syndromes (BMFS), including AA, constitute about 10-15%of all BMFS and up to 30% of paediatric BMFS ,with an average of 65 cases per million live births each year .Acquired AA remains the predominant from in older children and adolescent , while inherited forms are more common in younger children(3).The clinical presentation of aplastic anaemia regularly consists of symptoms associated with pancytopenia, including fatigue, pallor, bruising, bleeding, and extended susceptibility to infections(4). Identified etiologic risk factors include infections of viral origin, such as hepatitis-associated, Epstein-Barr, parvovirus, human immunodeficiency virus, varicella zoster, measles and other viruses, as well as exposure to toxic chemicals (e.g. benzene, pesticides and insecticides) and ionizing radiation (5). Over the last three decades, bone marrow transplantation (BMT) from a matched related donor (MRD) has been the treatment of choice for children with acquired AA (6) The Rationale of our study: aplastic anaemia in children is a serious ,life threatening bone marrow failure syndrome ,often resulting from immune-mediated destruction of hematopoietic stem cell triggered by factors such as viral infections, environmental toxin, or genetic predispositions and requires precise diagnosis to distinguish from inherited bone marrow failure syndromes or hypoplastic myelodysplastic syndrome to guide appropriate treatment strategies .

The Research question: What is the clinico-epidemiological profile of acquired aplastic anaemia among children at Assiut governorate.

Conditions

Acquired Aplastic Anaemia

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: OTHER

Interventions

observational case series study no intervention

Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2.Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 1- Children aged 1-18 years old diagnosed with acquired aplastic anemia 2-Fulfillment of the diagnostic criteria for acquired AA 3-patient with complete medical records,including diagnostic ,labaratory and treatement data 4-Diagnosed or treated at assuit university children hospital and the central health insurance clinic at assuit Governorate (october 2020 to october 2026)

Exclusion Criteria

• 1-children with congental bone marrow failure syndrome 2-patient with a history of chemotherapy or radiotherapy prior to diagnosis 2-cases with incomplete medical or insufficient medical records that prevented confirmination of diagnosis or extraction of essential study data

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Sara Ramadan Hassanein Hassan

Assistant Lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mostafa Mohamed Embaby, professor of pediatic

Role: PRINCIPAL_INVESTIGATOR

Departement of Familly medicine Assuit University

Central Contacts

Sara Ramadan Hassanein, Resident doctor

Role: CONTACT

sararamadan25399@gmail.com

+2001018426240

Hamdy Mohamed Mohamed, Lecturer at familly medicine

Role: CONTACT

dhamdy2003@med.aun.edu.eg

+2001000882184

Other Identifiers

Aplastic anemia in children .

Identifier Type: -

Identifier Source: org_study_id