Full Assessment of Clinical Transfusion Support

NCT ID: NCT07094646

Last Updated: 2025-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-21

Study Completion Date

2024-03-19

Brief Summary

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This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive. Researchers are using small samples of dried blood (called dried blood spots) from both the children and the donated blood to find out what might be causing the anemia.

Detailed Description

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This study includes children at Jinja Regional Referral Hospital (Jinja, Uganda) who need a blood transfusion, whether they are in the clinic, emergency room, or children's ward. After doctors finish the usual blood tests, a small sample of leftover blood will be saved on a special card (called a dried blood spot). The same will be done for all blood transfused during the study. These samples will be frozen and later sent to Cincinnati Children's Hospital for testing.

Conditions

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Sickle Cell Anemia Blood Transfusion Malaria Parasitaemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Wet Season - Transfusion

Those receiving a blood transfusion during the Eastern Uganda wet season.

No interventions assigned to this group

Dry Season - Transfusion

Those receiving a blood transfusion during the Eastern Uganda dry season.

No interventions assigned to this group

Wet Season - Donated

Transfusion units donated during the Eastern Uganda wet season.

No interventions assigned to this group

Dry Season - Donated

Transfusion units donated during the Eastern Uganda dry season.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Children receiving a blood transfusion in Eastern Uganda at Jinja Regional Referral Hospital.

Exclusion Criteria

* If receiving a blood transfusion, refusal or inability to sign an informed consent.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cincinnati Children's Hospital Medical Center (CCHMC)

UNKNOWN

Sponsor Role collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Russell E Ware, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Children's Hospital Medical Center, Cincinnati

Locations

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Jinja Regional Referral Hospital (JRRH)

Jinja, , Uganda

Site Status

Countries

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Uganda

Other Identifiers

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FACTS

Identifier Type: -

Identifier Source: org_study_id

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