Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
290 participants
INTERVENTIONAL
2013-02-28
2016-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Short-storage RBC
RBC transfusion using packed RBCs stored for 10 days or less.
RBC transfusion
RBC transfusion of different storage age
Prolonged-storage RBC
RBC transfusion using packed RBCs stored for 25 days or more.
RBC transfusion
RBC transfusion of different storage age
Interventions
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RBC transfusion
RBC transfusion of different storage age
Eligibility Criteria
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Inclusion Criteria
* Hg \< 5 g/dL and Lactate \> 5 mM
Exclusion Criteria
* Children with known or suspected cardiac disease
6 Months
5 Years
ALL
No
Sponsors
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Massachusetts General Hospital
OTHER
Responsible Party
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Walter H. Dzik
Co-Director, Blood Transfusion Service
Principal Investigators
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Walter H Dzik, MD
Role: PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital
Locations
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Mulago Hospital
Kampala, , Uganda
Countries
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References
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Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH. Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial. JAMA. 2015 Dec 15;314(23):2514-23. doi: 10.1001/jama.2015.13977.
Other Identifiers
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R21
Identifier Type: -
Identifier Source: org_study_id
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