Exercise Intensity and Postprandial Effects of Breaking Sedentary Behavior in Overweight Adults
NCT ID: NCT07229963
Last Updated: 2025-11-17
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
NOT_YET_RECRUITING
Clinical Phase
NA
Total Enrollment
16 participants
Study Classification
INTERVENTIONAL
Study Start Date
2025-11-25
Study Completion Date
2026-06-15
Brief Summary
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The purpose of this study is twofold: (1) to determine whether breaking up prolonged sitting with aerobic or sprint cycling breaks reduces postprandial blood glucose, insulin, CRP, and blood pressure, which are established risk markers for cardiometabolic diseases; and (2) to assess substrate oxidation during this period in order to identify which exercise condition promotes the greatest increase in fat oxidation.
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Detailed Description
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Sedentary behavior (SED) refers to activities such as sitting, lying down, or reclining that require energy expenditure of ≤1.5 MET during the time spent awake. Prolonged and continuous sedentary behavior leads to adverse effects such as abnormal postprandial metabolic responses, insulin resistance, vascular dysfunction, high blood pressure, increased carbohydrate oxidation, and inflammation. Epidemiological data also show that SED increases the risk of mortality, cardiovascular disease, type 2 diabetes, and certain types of cancer. Experimental studies have shown that 2-5 minutes of low- or moderate-intensity aerobic exercise performed every 20-30 minutes during the postprandial period improves cardiometabolic health by reducing glucose, insulin, and blood pressure during the postprandial period. On the other hand, it is known that short-term sprint interval exercise (SIE) increases insulin sensitivity by rapidly depleting muscle glycogen, improves glucose control, lowers blood pressure, and increases fat oxidation. With these effects, SIE may be a time-efficient method for interrupting SED. Although the cardiometabolic benefits of SIE and aerobic exercise interruptions (AEI) are known, there is a lack of studies comparing the effects of interrupting SED with these two exercise types of different intensities in preventing postprandial cardiometabolic dysfunction. In this context, the aim of the study is to compare the postprandial cardiometabolic effects of interrupting sedentary behavior with AIE and sprint exercise interruptions (SEI) in overweight but otherwise healthy women and men aged 35-45. In this randomized crossover trial, volunteers will participate in three trials: 1) AEI, 2) SEI, and 3) SED. There will be a minimum 3-day washout period between trials. In the SEI and AEI trials, exercise interruptions will be implemented every 30 minutes during the 7-hour sitting period, whereas in the SED trial, participants will remain seated continuously for the entire duration. In all conditions, two meals (breakfast and lunch) will be served 3 hours apart, and the trials will begin, after the breakfast meal is consumed. Venous blood samples taken hourly during the experiment will be used to analyze insulin, glucose, and C-reactive protein (CRP) levels. In addition, blood pressure will be measured hourly, and fat oxidation will be assessed at the baseline, 2nd, 5th, and 7th hours. The effects of the conditions on glucose and insulin will be evaluated using linear mixed models. A Two-Way (Trial x Number of Repeats) Analysis of Variance for Repeated Measures will be used to detect differences between conditions.
Conditions
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Cardiovascular Risk Markers
Substrate Oxidation
Postprandial Metabolism
Exercise Physiology
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
CROSSOVER
Primary Study Purpose
PREVENTION
Blinding Strategy
NONE
Study Groups
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Sedentary: Participants will remain seated for 7 h.
The sedentary condition will take place in a seated position. During the seated condition, volunteers will be seated at a typical desk chair at an appropriate height with hip and knee angles of \~90° and feet flat on the floor. The seating area will include a standard desk chair, a work desk, and the volunteers' personal laptops. Volunteers will be instructed prior to the visit to avoid behaviors such as fidgeting, excessive leg movements, and crossing their legs to minimize potential extraneous effects.
Group Type
EXPERIMENTAL
Sedentary Behaviour Intervention
Intervention Type
OTHER
Participants will remain seated for a total duration of 7 hours. During this period, they will be instructed to minimize excessive movement and will only be permitted to rise from the chair for voiding purposes.
Breaking up sitting with aerobic exercise interruptions
The protocol that will interrupt sitting with AEI will involve cycle exercises performed at 50% of VO2max for 2 minutes. The W and rpm levels corresponding to 50% of VO2max will be determined using the values recorded during the determination of VO2max.
Group Type
EXPERIMENTAL
Aerobic Exercise Intervention
Intervention Type
OTHER
In the aerobic exercise condition, participants will perform 2 minutes of moderate-intensity continuous cycling.
Breaking up sitting with sprint exercise interruptions
The protocol that will interrupt sitting with SEI will involve cycle exercises performed at the maximum revolutions per minute achievable within 10 seconds. Immediately before each SEI, volunteers will increase their pedal cadence to the maximum speed they can achieve, after which a pedal load will be applied to the bicycle ergometer and a sprint will be performed against the applied load for 10 seconds. During each sprint, the pedal load will be applied at 0.065 kilograms per kilogram of lean body mass. Since it has been shown to lead to greater peak power output in overweight and obese groups, lean body mass will be used as a reference when determining pedal load, rather than total body mass.
Group Type
EXPERIMENTAL
Sprint Exercise Intervention
Intervention Type
OTHER
In the sprint condition, participants will complete a 10-second all-out sprint, as determined during the preliminary test.
Interventions
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Aerobic Exercise Intervention
In the aerobic exercise condition, participants will perform 2 minutes of moderate-intensity continuous cycling.
Intervention Type
OTHER
Sprint Exercise Intervention
In the sprint condition, participants will complete a 10-second all-out sprint, as determined during the preliminary test.
Intervention Type
OTHER
Sedentary Behaviour Intervention
Participants will remain seated for a total duration of 7 hours. During this period, they will be instructed to minimize excessive movement and will only be permitted to rise from the chair for voiding purposes.
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
* Being physically inactive (not doing at least 150 minutes/week of structured exercise).
* Having a physical activity level of \<5000 steps/day.
* Having a BMI between 25 and 29.9 kg/m2.
* Having a history of regular menstrual cycles for female participants.
* Having medical examination approval.
* Having a physical activity level of \<5000 steps/day.
* Having a BMI between 25 and 29.9 kg/m2.
* Having a history of regular menstrual cycles for female participants.
* Having medical examination approval.
Exclusion Criteria
* Taking any acute or chronic medication or supplement that may affect metabolism.
* Having an acute or chronic illness that limits exercise (musculoskeletal problems, cardiovascular disorders, respiratory problems, etc.).
* Consuming tobacco products.
* Meeting 3 or more of the metabolic syndrome criteria (waist circumference of 102 cm or more in men, 88 cm or more in women, triglyceride level of 150 mg/dL or higher, HDL cholesterol level below 40 mg/dL in men and 50 mg/dL in women, blood pressure of 130/85 mmHg or higher, fasting blood glucose level of 100 mg/dL (5.6 mg/L) or higher).
* Having an acute or chronic illness that limits exercise (musculoskeletal problems, cardiovascular disorders, respiratory problems, etc.).
* Consuming tobacco products.
* Meeting 3 or more of the metabolic syndrome criteria (waist circumference of 102 cm or more in men, 88 cm or more in women, triglyceride level of 150 mg/dL or higher, HDL cholesterol level below 40 mg/dL in men and 50 mg/dL in women, blood pressure of 130/85 mmHg or higher, fasting blood glucose level of 100 mg/dL (5.6 mg/L) or higher).
Minimum Eligible Age
35 Years
Maximum Eligible Age
45 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
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Hacettepe University Scientific Research Projects Coordination Unit
UNKNOWN
Sponsor Role
collaborator
Hacettepe University
OTHER
Sponsor Role
lead
Responsible Party
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Muhammed Mustafa Atakan
Associate Professor
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Şükran Nazan Koşar, Professor
Role: PRINCIPAL_INVESTIGATOR
Hacettepe University
Locations
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Hacettepe Sports Science Faculty, Hacettepe Beytepe Clinic
Ankara, Beytepe, Turkey (Türkiye)
Site Status
Countries
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Turkey (Türkiye)
Central Contacts
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Facility Contacts
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References
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BACKGROUND
Other Identifiers
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SBA 25/679
Identifier Type: -
Identifier Source: org_study_id
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COMPLETED
NA
Effect of Breaking up Prolonged Sitting on Metabolic Flexibility
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COMPLETED
NA
Effects of Diet Versus Diet Plus Aerobic and Resistant Exercise Program in Overweight Women
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SUSPENDED
NA
Exercise Intensity and Type 2 Diabetics
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COMPLETED
NA
Effect of Aerobic Exercise and Mediterranean Diet on Obese Patients
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COMPLETED
NA
Metabolic Dynamics During Physical Activity
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COMPLETED
NA
Efficacy of High-intensity Exercise in Women With Prediabetes
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ACTIVE_NOT_RECRUITING
NA
Effects of Standing and Light-intensity Activity on Ambulatory Blood Pressure and Blood Glucose
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COMPLETED
PHASE3
FIT 2 SIT - Are Metabolic Responses to Sitting/Light Breaks Mediated by Fitness?
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COMPLETED
NA
Home-Based Tele-Exercise vs. Hospital-Based Exercise Programs in Patients With Prediabetes
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ACTIVE_NOT_RECRUITING
NA