Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

NCT ID: NCT07226908

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-01

Study Completion Date

2029-08-31

Brief Summary

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The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of cortico-thalamic ictal propagation matches the intrinsic connectivity maps identified in the same individuals (Aim 2), and the effect of ANT and PLV stimulations on memory formation (Aim 3).

Detailed Description

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Conditions

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Epilepsy

Keywords

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Intracranial Electroencephalography

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Epilepsy Patients with Thalamic Electrode Implants

Patients will undergo cognitive testing and electrical stimulation experiments.

Group Type OTHER

Cognitive experiment

Intervention Type OTHER

Record brain activity during memory encoding

Electrical stimulation of the brain

Intervention Type OTHER

Measure accuracy and reaction time during cognitive tasks

Interventions

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Cognitive experiment

Record brain activity during memory encoding

Intervention Type OTHER

Electrical stimulation of the brain

Measure accuracy and reaction time during cognitive tasks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* No medical or surgical contraindication to electrode implantation
* Patient capable of understanding the scope of our project or signing informed consent independently

Exclusion Criteria

* Unable to provide informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Josef Parvizi

Professor of Neurology and Neurological Sciences (Adult Neurology)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Josef Parvizi, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Stanford Hospital

Stanford, California, United States

Site Status

Countries

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United States

Other Identifiers

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1R01NS137650-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

11354

Identifier Type: -

Identifier Source: org_study_id