tFUS Imaging & LIFU

NCT ID: NCT07222865

Last Updated: 2025-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2028-06-30

Brief Summary

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This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).

Detailed Description

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A battery of tasks will be performed under two imaging conditions. Magnetic Resonance Imaging and transcranial functional ultrasound imaging. Tasks include a breath hold task, an e-stim task, and low-intensity focused ultrasound neuromod.

Conditions

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Brain Imaging

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All participants will complete all study visits - fMRI + tasks, tFUS + tasks, and tFUS + LIFU.
Primary Study Purpose

DEVICE_FEASIBILITY

Blinding Strategy

NONE

Study Groups

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Arm 1 - all participants

All participants will receive two imaging modalities with corresponding tasks to compare imaging modalities.

Group Type EXPERIMENTAL

Feasibility of imaging using tFUS

Intervention Type DEVICE

Imaging using transcranial functional ultrasound.

Interventions

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Feasibility of imaging using tFUS

Imaging using transcranial functional ultrasound.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* See above.

Exclusion Criteria

* Claustrophobia
* Contraindications to MRI (neurostims, metal implants, pacemakers, etc)
* Contraindications to CT (pregnancy)
* Active medical disorders with CNS effects (e.g. Alzheimers)
* History of neurological disorder
* History of head injury with LOC \> 10 min
* History of alcohol or drug dependence
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Virginia Polytechnic Institute and State University

OTHER

Sponsor Role lead

Responsible Party

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Wynn Legon

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Fralin Biomedical Research Institute at VTC

Roanoke, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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25-953

Identifier Type: -

Identifier Source: org_study_id

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