Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
NCT ID: NCT06829368
Last Updated: 2025-09-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
20 participants
INTERVENTIONAL
2025-01-20
2025-12-31
Brief Summary
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Detailed Description
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Each participant will attend four sessions, with each session dedicated to one of the brain structures or the sham site. Sessions consist of three distinct phases: (1) a pre-stimulation phase (task completion prior to tFUS), (2) an on-stimulation phase (task completion concurrent with tFUS), and (3) a post-stimulation phase (task completion following tFUS, with EEG recording). The Object in Place task will be used to assess vWM, requiring participants to recall the colour of abstract objects based on their location or shape.
Primary outcomes focus on both immediate (acute) and delayed (post-stimulation) behavioural changes in task performance, as well as neurophysiological EEG markers indicative of working memory processes. Moreover, the investigators will monitor for immediate and longer-term side effects. Stimulation is administered in a theta-burst pattern for 5 minutes, covering a portion of the task trials during the on-stimulation phase.
This study compares tFUS effects across various deep cortical and subcortical structures, examining acute and post-stimulation cognitive changes and monitoring immediate and longer-term side effects. Findings are expected to offer new insights into the potential of tFUS-based neuromodulation as a tool for cognitive enhancement.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Mediodorsal Thalamus Stimulation
Theta-burst tFUS targeting the mediodorsal thalamus
Transcranial Focused Ultrasound Stimulation
Using MRI neuronavigation, the investigators will implement theta-burst tFUS in one of the four targets.
Dorsal Anterior Cingulate Cortex Stimulation
Theta-burst tFUS targeting the dorsal anterior cingulate cortex
Transcranial Focused Ultrasound Stimulation
Using MRI neuronavigation, the investigators will implement theta-burst tFUS in one of the four targets.
Anterior Insula Stimulation
Theta-burst tFUS targeting the anterior insula
Transcranial Focused Ultrasound Stimulation
Using MRI neuronavigation, the investigators will implement theta-burst tFUS in one of the four targets.
Lateral Ventricle Stimulation
Theta-burst tFUS targeting the lateral ventricle.
Transcranial Focused Ultrasound Stimulation
Using MRI neuronavigation, the investigators will implement theta-burst tFUS in one of the four targets.
Interventions
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Transcranial Focused Ultrasound Stimulation
Using MRI neuronavigation, the investigators will implement theta-burst tFUS in one of the four targets.
Eligibility Criteria
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Inclusion Criteria
* Healthy adults with no history of neurological or psychiatric disorders
* Eligible to undergo a T1-weighted MRI scan for tFUS neuronavigational purposes
* Ability to adhere to the tFUS study schedule and complete all assessments
* Right-handed
* Fluent in English
* Abstinence from the use of any recreational drugs in the 48-hour period prior to taking part in the experiment.
* Abstinence from consuming no more than 4 alcoholic units within the 24-hour period before participation.
Exclusion Criteria
* Neurodevelopmental disorders; history of central nervous system disease, concussion, or other neurological sequelae; presence of tumors, seizures, meningitis, encephalitis, or any abnormal MRI findings of the brain
* Use of any psychotropic medications within five half-lives before the procedure
* Presence of metal implants contraindicated for MRI
* History of head trauma with loss of consciousness
* Calcification in sonicated parts of the brain.
* Visual impairments that cannot be corrected with glasses
* Inability to complete cognitive testing requirements
* Active participation or plans for enrollment in other clinical trials that may impact psychosocial functioning
* History of repeated substance abuse or dependence (excluding nicotine and caffeine); use of medications such as stimulants, modafinil, thyroid medication, or steroids
* No skin disease on or close to the scalp.
* History of seizure or epilepsy; use of medications that lower seizure thresholds
* Claustrophobia or any other condition precluding MRI assessment
* Pregnancy or breastfeeding
18 Years
55 Years
ALL
Yes
Sponsors
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University of Nottingham
OTHER
Responsible Party
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Marcus Kaiser
Professor of Neuroinformatics
Principal Investigators
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Marcus Kaiser, Professor of Neuroinformatics
Role: PRINCIPAL_INVESTIGATOR
University of Nottingham
Mohammad Katshu, Clinical Associate Professor
Role: PRINCIPAL_INVESTIGATOR
University of Nottingham
Locations
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Neuromodulation Lab, Medical School, Queen's Medical Centre
Nottingham, Nottinghamshire, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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F1558
Identifier Type: -
Identifier Source: org_study_id
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