Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
20 participants
INTERVENTIONAL
2026-01-31
2027-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Radiation Therapy
Patients with early-stage, non-genetic, unilateral Parkinson's Disease who will receive an ultra-low, anti-inflammatory dose of radiation therapy.
Radiation therapy
Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) 60cGy once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.
Interventions
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Radiation therapy
Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) 60cGy once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Diagnosis of Parkinson's disease by a Movement Disorder Neurologist
* Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan
* A score of 2 or less on the modified Hoehn and Yahr scale
* ECOG Performance Status (PS) ≤ 2 (Appendix I).
* No known genetic causes or predisposition to Parkinson's disease or related diseases.
* Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance
* Ability to provide written informed consent
* Willing to provide mandatory blood samples for correlative research purposes
* Willing to return to enrolling institution for follow-up
Exclusion Criteria
* Parkinson's Disease medication changes within the last 3 months
* Receipt of radiation therapy for Parkinson's Disease outside Mayo Clinic, Rochester
45 Years
70 Years
ALL
No
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Yasamin Sharifzadeh-Moghaddam
Principal Investigator
Principal Investigators
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Yasamin Sharifzadeh-Moghaddam
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Other Identifiers
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24-006978
Identifier Type: -
Identifier Source: org_study_id
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