Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
78 participants
OBSERVATIONAL
2010-02-28
2019-02-28
Brief Summary
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1. The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate will be higher due to mitochondrial dysfunction, the gliosis markers myo-inositol and glutamine will be higher due to inflammation (glial activation) and N-acetylaspartate and glutamate will be lower due to neuronal loss/damage.
2. There will be a relationship between neurochemical changes and disease severity.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Parkinson's disease (clinical diagnostic criteria)
* Age 45-75 years inclusive
* Able to safely undergo MRI scanning
* Absence of diabetes and smoking
* Capable of giving informed consent
Healthy Control Group
* Age 45-75 years inclusive
* Able to safely undergo MRI scanning
* Absence of diabetes and smoking
* Capable of giving informed consent
Exclusion Criteria
* Dementia (clinically determined by PI Dr. Tuite)
* Diagnosis of atypical parkinsonism
* Inability to safely undergo MRI scanning
* Inability to give informed consent
* Unstable medical conditions
* Present smoker
* Diabetic (on oral or injectable medications for diabetes)
* Taken coenzyme Q10 or Vitamin E in the 2 weeks prior to the scan
* Does not meet age criteria
Healthy Control Group
* Has a 1st degree relative with PD
* Dementia (clinically determined by PI Dr. Tuite)
* Inability to safely undergo MRI scanning
* Inability to give informed consent
* Unstable medical conditions
* Present smoker
* Diabetic (on oral or injectable medications for diabetes)
* Taken coenzyme Q10 or Vitamin E in the 2 weeks prior to the scan
* Does not meet age criteria
45 Years
75 Years
ALL
Yes
Sponsors
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University of Minnesota
OTHER
Responsible Party
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Principal Investigators
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Paul Tuite, MD
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Locations
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University of Minnesota/CMRR
Minneapolis, Minnesota, United States
Countries
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Other Identifiers
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0803M28421
Identifier Type: -
Identifier Source: org_study_id
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