Adaptive DBS to Offset STN Dysregulation During Exercise in PD

NCT ID: NCT06296810

Last Updated: 2025-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-01

Study Completion Date

2025-12-31

Brief Summary

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The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.

Detailed Description

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The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.

Conditions

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Parkinson Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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PD

Subjects with PD who have an implanted Medtronic DBS system with a Percept IPG.

aDBS

Intervention Type DEVICE

adaptive deep brain stimulation

Interventions

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aDBS

adaptive deep brain stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.

\-

Exclusion Criteria

Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Colorado, Denver

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Colorado

Aurora, Colorado, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Pamela David Gerecht, PhD

Role: CONTACT

303-724-4134

Facility Contacts

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Pamela David Gerecht, PhD

Role: primary

303-724-4134

Other Identifiers

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23-0847

Identifier Type: -

Identifier Source: org_study_id

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