Economic Evaluation of Mindline.sg

NCT ID: NCT07209904

Last Updated: 2026-01-15

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 300 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-11-20
• Study Completion Date: 2026-03-31

Brief Summary

This study aims to evaluate the effectiveness of mindline.sg, a digital mental health platform, in improving mental health literacy, emotional wellbeing, quality of life, and economic outcomes among adults in Singapore. We will conduct a randomized controlled trial (RCT) with two phases: an initial screening and a 1-month intervention. Eligible participants, identified based on mental health symptom scores, will be randomly assigned to either an intervention group using mindline.sg or a control group receiving standard mental health information.

The intervention group will receive weekly prompts to engage with key features of the platform, including psychoeducation, positive psychology tools, emotion regulation exercises, and access to digital navigation for mental health services. Participants in both groups will complete surveys at baseline, post-intervention, and two months post-intervention, measuring outcomes such as mental health symptoms, resilience, wellbeing, emotion regulation, mental health literacy, and work performance. We expect mindline.sg users to show greater improvements across mental health and quality of life indicators, increased mental health literacy, and better work productivity compared to controls. This study will provide evidence on the utility of digital mental health tools in supporting population mental wellbeing and inform future digital mental health strategies in Singapore and similar contexts.

Detailed Description

The primary hypothesis is:

• Participants in the intervention group using mindline.sg will show significantly greater improvements in mental health outcomes, quality of life, and work productivity at post-intervention (T1) and 3-month follow-up (T2), compared to the control group.

Secondary hypotheses include:

• Intervention participants will demonstrate increased resilience, better emotion regulation, and more positive attitudes and behaviors toward mental health help-seeking compared to the control group.
• Participants in the intervention group will show higher usage and engagement with digital mental health features and report higher perceived helpfulness of tools.
• The mindline.sg intervention will be cost-effective compared to the control condition, considering improvements in mental health and productivity outcomes relative to platform costs.

The study will use a randomized controllled trial design. Participants will be assigned to either: (1) A control group (receiving a mental health information pamphlet), or (2) An intervention group (using mindline.sg). Primary outcomes include mental health status, quality of life, economic and productivity measures, and user engagement metrics.

Trial participation will last 3 months. We aim to screen 5,000 adults from the general population who are aged 21 and above, have lived in Singapore for at least two years, have no psychiatric history, and are not currently receiving mental health treatment.

Participants from screening whose DASS-21 scores are mild to moderate for any one of the following sub scales will be recruited for the subsequent phase of the study.

Participants will be randomly assigned to either the control or intervention group. In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore (e.g., from the Health Promotion Board). In the intervention group, participants will be encouraged to use Mindline.sg for four weeks.

The intervention includes weekly prompts to engage with different platform features, for example:

• Week 1: Mental health literacy (Self-assessment tools and psychoeducation modules e.g. 'understand stress', 'find perspective')
• Week 2: Positive psychology and meditation exercises through Wysa AI chat (Completion of at least 4 exercises, e.g. 'Feel more control', 'be grateful', 'think motivation', 'identify your strengths', 'be kind to yourself', 'offload your worries', 'talk about your day'). Do note that Wysa's AI materials are carefully assessed for mental health appropriateness. Users can access the Wysa AI chat directly through the mindline platform without any further registration or account creation.
• Week 3: Emotion regulation exercises on mindline.sg platform (eg: tackling emotional burnout, overcoming insecurity, overcoming low mood and regaining motivation)
• Week 4: Help-seeking and personalized toolkit (explore service wayfinding tools for further mental health resources, mindline.sg live chat).

Participants will not be required to download any third party app. They are also not required to disclose any personal data during registration or use of the mindline.sg platform. Weekly activities will likely take between 10 - 30 mins, depending on the activities. Participants can exit and come back to the website later and continue their activities at their own pace. Each week, participants will receive weekly reminders via phone (e.g. messenger app) or email. This will contain infographics explaining the features.

Additionally, to ensure compliance, participants will be given a quiz at the end of each week with reimbursements for quiz completion. At the end of each week, they will also be asked to report on their use of site features (frequency and feature(s) used, and perceived helpfulness of feature), as well as their mood (three visual-analogue scales tracking: overall mood, stress, and ability to cope with challenges during the week). The quizzes will focus on participants' engagement with the platform, user experience, satisfaction, and feedback on specific features-such as what they liked or didn't like, and what worked well or didn't work. There are no "right" or "wrong" answers.

Reimbursement will be based on completeness of the quiz, not correctness-so as long as participants complete all the questions, they will be eligible.

The peer support forum feature (Let's Talk) on the mindline platform will not be part of the package as there is a separate study to evaluate it specifically.

At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they too can benefit from it.

(b) Participants will also complete measures at three time-points: baseline (T0), immediately after the intervention (T1), and 2-months post-intervention. Across the three measurement timepoints, participants will be asked to complete a questionnaire to measure primary and secondary outcomes.

To provide further context, we will analyse aggregated and anonymised administrative data from the platform during the study period, including:

• Referrals: Referrals (self-reported) from mineline.sg to offline mental health services;
• Costs of mindline, including: Development and operational costs.

Please note that this project is a collaborative initiative between the Behavioural and Implementation Sciences Interventions (BISI) at YLLSoM, NUS, the Centre for Evidence and Implementation (CEI), and Ministry of Health Office for Healthcare Transformation (MOHT) formalized through a project contract signed among the three organisations. The project is supported with funding from MOHT.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: DOUBLE

Study Groups

Control

In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore. At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they can benefit from it.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Intervention

In the intervention group, participants will be encouraged to use Mindline.sg for four weeks. Each week, participants will receive a reminder to complete certain activities on the website and a quiz to measure completion of activities.

Group Type: EXPERIMENTAL

mindline.sg

Intervention Type: BEHAVIORAL

mindline.sg is a polydigital mental health platform with resources, wayfinding, and peer support via a forum. The website was built by the MOH Office for Healthcare Transformation together with Ministry of Social and Family Development, National Council of Social Service and Institute of Mental health. The content was cureated by the mindline.sg team and vetted by a clinical review panel which included clinicians from IMH and Fei Yue Community Services.

Interventions

mindline.sg

mindline.sg is a polydigital mental health platform with resources, wayfinding, and peer support via a forum. The website was built by the MOH Office for Healthcare Transformation together with Ministry of Social and Family Development, National Council of Social Service and Institute of Mental health. The content was cureated by the mindline.sg team and vetted by a clinical review panel which included clinicians from IMH and Fei Yue Community Services.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Aged at least 21 years or at least 18 years old if National of University student
• Have lived in Singapore for at least 2 years
• Have not received a formal diagnosis of a psychiatric disorder
• Not currently receiving any form of mental health treatment (e.g., counselling)
• Fluent in English
• Participants from screening whose DASS-21 scores are mild or moderate for any one of the sub scales.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

MOH Office for Healthcare Transformation (MOHT), Singapore

UNKNOWN

Sponsor Role: collaborator

National University of Singapore, Behavioural and Implementation Science Interventions

UNKNOWN

Sponsor Role: collaborator

Centre for Evidence and Implementation Singapore Ltd

OTHER

Sponsor Role: lead

Responsible Party

Jean Liu

Associate Director

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jean Liu, PhD

Role: PRINCIPAL_INVESTIGATOR

National University of Singapore, Yong Loo Lin School of Medicine.

Locations

National University of Singapore

Singapore, , Singapore

Countries

Singapore

References

Tan EY, Wee RR, Saw YE, Heng KJ, Chin JW, Tong EM, Liu JC. Tracking Private WhatsApp Discourse About COVID-19 in Singapore: Longitudinal Infodemiology Study. J Med Internet Res. 2021 Dec 23;23(12):e34218. doi: 10.2196/34218.

Reference Type: BACKGROUND

PMID: 34881720 (View on PubMed)

Barsova T, Cheong ZG, Mak AR, Liu JC. Predicting Psychological Symptoms When Facebook's Digital Well-being Features Are Used: Cross-sectional Survey Study. JMIR Form Res. 2022 Aug 29;6(8):e39387. doi: 10.2196/39387.

Reference Type: BACKGROUND

PMID: 36036971 (View on PubMed)

Erdembileg, S., Asplund, C. L., & Liu, J. C. J. (in preparation). Engagement with Taylor Swift's music and social media content predicts mental health outcomes in youths: Cross-sectional survey study.

Reference Type: BACKGROUND

Saw YE, Tan EY, Liu JS, Liu JC. Predicting Public Uptake of Digital Contact Tracing During the COVID-19 Pandemic: Results From a Nationwide Survey in Singapore. J Med Internet Res. 2021 Feb 3;23(2):e24730. doi: 10.2196/24730.

Reference Type: BACKGROUND

PMID: 33465034 (View on PubMed)

Other Identifiers

NUS-IRB-2025-228

Identifier Type: -

Identifier Source: org_study_id