Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3)

NCT ID: NCT07194915

Last Updated: 2025-09-26

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 326 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-01-09
• Study Completion Date: 2025-10-01

Brief Summary

Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activity. The investigators examined the biological role of pleural fluid neutrophil extracellular traps in patients with pleural infection. TORPIDS-3 is an observational, International multicohort study.

Conditions

Pleural Infection

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

PILOT

Pleural fluid specimens collected for the PILOT study

No interventions assigned to this group

Oxford Pleural Biobank

Pleural fluid specimens collected in Oxford

No interventions assigned to this group

Oxford-Osler

Pleural fluid specimens collected in Oxford

No interventions assigned to this group

Patras Pleural Biobank

Pleural fluid specimens collected in Patras, Greece

No interventions assigned to this group

Ancona Pleural Biobank

Pleural fluid specimens collected in Ancona, Italy

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

Patients were included if they had a clinical presentation consistent with pleural infection as stated in the Methods section of the main manuscript and any of the following criteria:

1. Pleural fluid that was macroscopically purulent, OR

2. Pleural fluid that was positive on culture for bacterial infection, OR

3. Pleural fluid that demonstrated bacteria on Gram staining, OR

4. Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR

5. Contrast-enhanced CT evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection.

Exclusion Criteria

1. Age less than 18 years, OR

2. No pleural fluid available for analysis, OR

3. Patient previous pneumonectomy on the side of pleural infection, OR

4. Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Dundee

OTHER

Sponsor Role: collaborator

University of Oxford

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CAMS Oxford Institute, Nuffield Department of Medicine

Oxford, , United Kingdom

Countries

United Kingdom

References

Corcoran JP, Psallidas I, Gerry S, Piccolo F, Koegelenberg CF, Saba T, Daneshvar C, Fairbairn I, Heinink R, West A, Stanton AE, Holme J, Kastelik JA, Steer H, Downer NJ, Haris M, Baker EH, Everett CF, Pepperell J, Bewick T, Yarmus L, Maldonado F, Khan B, Hart-Thomas A, Hands G, Warwick G, De Fonseka D, Hassan M, Munavvar M, Guhan A, Shahidi M, Pogson Z, Dowson L, Popowicz ND, Saba J, Ward NR, Hallifax RJ, Dobson M, Shaw R, Hedley EL, Sabia A, Robinson B, Collins GS, Davies HE, Yu LM, Miller RF, Maskell NA, Rahman NM. Prospective validation of the RAPID clinical risk prediction score in adult patients with pleural infection: the PILOT study. Eur Respir J. 2020 Nov 26;56(5):2000130. doi: 10.1183/13993003.00130-2020. Print 2020 Nov.

Reference Type: BACKGROUND

PMID: 32675200 (View on PubMed)

Other Identifiers

TORPIDS-3

Identifier Type: -

Identifier Source: org_study_id