Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients

NCT ID: NCT07188272

Last Updated: 2025-09-23

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-07-10
• Study Completion Date: 2026-01-01

Brief Summary

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide . It is necessary to reduce the incidence and risk factors of CVD, as physical activity is known to reduce mortality from CVD. Arterial stiffness and hypertension are closely related in pathophysiology. Chronic high blood pressure (BP) can lead to arterial wall damage by mechanical stress, endothelial dysfunction, increased inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation. HIIT has been shown to be equally or even better at stimulating health benefits than moderate-intensity continuous training (MICT) and is considered a time-saving aerobic exercise for reducing arterial stiffness in HTN patients

Conditions

Hypertension; Arterial Stiffness

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

DASH diet group

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT) combined with DASH diet.

Group Type: EXPERIMENTAL

DASH diet

Intervention Type: DIETARY_SUPPLEMENT

Eating vegetables, fruits, and whole grains Including fat-free or low-fat dairy products, fish, poultry, beans, nuts, and vegetable oils Limiting foods that are high in saturated fat, such as fatty meats, full-fat dairy products, and tropical oils such as coconut, palm kernel, and palm oils Limiting sugar-sweetened beverages and sweets

Comparator group

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT)

Group Type: ACTIVE_COMPARATOR

High Intensity Interval Training

Intervention Type: PROCEDURE

High Intensity Interval Training

Interventions

DASH diet

Eating vegetables, fruits, and whole grains Including fat-free or low-fat dairy products, fish, poultry, beans, nuts, and vegetable oils Limiting foods that are high in saturated fat, such as fatty meats, full-fat dairy products, and tropical oils such as coconut, palm kernel, and palm oils Limiting sugar-sweetened beverages and sweets

Intervention Type: DIETARY_SUPPLEMENT

High Intensity Interval Training

High Intensity Interval Training

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Their age< 35 up to 50 years old
• Both sexes.
• Controlled HTN ( stage 1,B.P 140-159 mmhg / 90-99 mmhg and stage 2, B.P 160-179 mmhg-100-109 mmhg )
• Hemodynamic stable. Able to provide informed consent

Exclusion Criteria

• Uncontrolled hypertension.
• Severe HTN <180/110 mmhg
• Renal dysfunction
• Unstable cardiac conditions
• Severe pulmonary disease that limit exercise
• Impaired cognition
• Musculoskeletal problems that made it difficult to do exercise

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Deraya University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Waleed Mohamed Abdelmohsen Abdelsalalm

Minya, , Egypt

Site Status: RECRUITING

Countries

Egypt

Facility Contacts

Soad A. Mohamad

Role: primary

ph.soadali@yahoo.com

01003621641

Other Identifiers

September 2025

Identifier Type: -

Identifier Source: org_study_id