Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

NCT ID: NCT04830995

Last Updated: 2023-01-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-03-24
• Study Completion Date: 2020-11-01

Brief Summary

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Detailed Description

This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by "Diamond Diagnostics," while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

Conditions

High Intensity Interval Training; Diet, Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

diet program

moderate restricted diet (1800-2000 kcal/day) for four weeks, 3 sessions weekly

Group Type: EXPERIMENTAL

moderate restricted diet (1800-2000 kcal/day) for four weeks

Intervention Type: DIETARY_SUPPLEMENT

high intensity interval training 3 sessions for four weeks

high intensity interval training

high intensity interval training for four weeks, 3 sessions weekly

Group Type: EXPERIMENTAL

moderate restricted diet (1800-2000 kcal/day) for four weeks

Intervention Type: DIETARY_SUPPLEMENT

high intensity interval training 3 sessions for four weeks

Interventions

moderate restricted diet (1800-2000 kcal/day) for four weeks

high intensity interval training 3 sessions for four weeks

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

high intensity interval training

Eligibility Criteria

Inclusion Criteria

• forty multigravida females.
• their age ranged between 25 to 35 years old.
• Body mass index (BMI) <30kg/ m².

Exclusion Criteria

• females with pelvic pathology as endometriosis.
• females have irregular menstrual cycles.

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Heba mohamed Embaby

UNKNOWN

Sponsor Role: collaborator

Salwa Elgendy

UNKNOWN

Sponsor Role: collaborator

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Ghada Ebrahim El Refaye

assistant professor Department of Physical Therapy for Women's Health, Faculty of Physical therapy, Cairo University, Egypt

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Ghada Elrefaye

Giza, , Egypt

Countries

Egypt

Other Identifiers

Cairo Un100

Identifier Type: -

Identifier Source: org_study_id