Clinical Features and Prognosis of Takayasu's Arteritis With Pulmonary Arteries Involvement

NCT ID: NCT07184814

Last Updated: 2025-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2026-12-31

Brief Summary

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The purpose of this study is to identify the clinical features, management pattern and long-term outcomes of patients with pulmonary arteries involvement in Takayasu's arteritis (TAK-PAI).

Detailed Description

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The present study intends to conduct a prospective analysis of the clinical data in TAK patients in order to:

1. describe the clinical characteristics and current status of multimodal treatment in patients with TAK-PAI, thereby enhancing the understanding of TAK-PAI;
2. to investigate the risk factors for mortality in patients with TAK-PAI, so as to promote early intervention and reduce mortality.
3. explore factors associated with pulmonary hypertention (PH) in patients with TAK-PAI, so as to facilitate the early identification of patients who may develop PH.

Conditions

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Takayasu Arteritis With Pulmonary Artery Involvement Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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TAK-PAI group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Hospitalized between Jan 1, 2016 and Dec 31, 2026
* Diagnosed with TAK according to the modified Ishikawa criteria and/or 1990 American College of Rheumatology criteria and/or 2022 ACR/EULAR criteria
* Diagnosed with pulmonary artery involvement using computed tomography pulmonary angiography or transcatheter pulmonary angiography
* Patients without aortic or primary branch involvement who nonetheless exhibited both clinical features and computed tomography-confirmed evidence of pulmonary artery involvement (PAI), after exclusion of other diseases causing pulmonary artery stenosis or occlusion

Exclusion Criteria

* Patients with PAI caused by non-TAK diseases such as other types of vasculitis, fibrosing mediastinitis, pulmonary artery sarcoma, pulmonary sarcoidosis or chronic thromboembolic pulmonary hypertension
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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China-Japan Friendship Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wanmu Xie

Director, Department of Integrative Pulmonary Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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China-Japan Friendship hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wanmu Xie, Doctor

Role: CONTACT

15611734410

Facility Contacts

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Wanmu Xie, Doctor

Role: primary

15611734410

Other Identifiers

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2022-NHLHCRF-LX-01-01-02

Identifier Type: -

Identifier Source: org_study_id

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