A Phase 3 Trial of OPA-15406 Foam in Children and Infants With Atopic Dermatitis

NCT ID: NCT07184645

Last Updated: 2025-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

198 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-30

Study Completion Date

2027-02-28

Brief Summary

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To investigate the superiority of 0.3% OPA-15406 foam to the vehicle in children with atopic dermatitis (AD)

Detailed Description

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Conditions

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Atopic Dermatitis (AD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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OPA-15406 foam

Group Type EXPERIMENTAL

OPA-15406

Intervention Type DRUG

0.3% foam or 1% foam, topical, twice daily, for 8 weeks

Vehicle

Group Type EXPERIMENTAL

Vehicle

Intervention Type DRUG

vehicle, topical, twice daily, for 8 weeks

Interventions

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OPA-15406

0.3% foam or 1% foam, topical, twice daily, for 8 weeks

Intervention Type DRUG

Vehicle

vehicle, topical, twice daily, for 8 weeks

Intervention Type DRUG

Other Intervention Names

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difamilast

Eligibility Criteria

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Inclusion Criteria

* Participants who have been diagnosed with AD based on the Diagnostic Criteria for Atopic Dermatitis (Criteria of the Japanese Dermatological Association)
* Participants who have an affected area covering from 5% to 40% of their body surface area (excluding the scalp) at the screening and baseline examinations
* Participants with an IGA score of 2 or 3 at the screening and baseline examinations

Exclusion Criteria

* Participants who experienced an acute exacerbation of AD or contact dermatitis within 28 days prior to the baseline examination
* Participants who have been treated with OPA-15406 ointment in the past
Minimum Eligible Age

3 Months

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nobuhito Sanada

Role: STUDY_DIRECTOR

Otsuka Pharmaceutical Co., Ltd.

Locations

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Sumire Dermatology Clinic

Tokyo, , Japan

Site Status

Countries

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Japan

Central Contacts

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Drug Information Center

Role: CONTACT

+81-3-6361-7314

Other Identifiers

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271-102-00044

Identifier Type: -

Identifier Source: org_study_id

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