A Safety Study to Evaluate the Use and Effectiveness of a Topical Ointment to Treat Adults With Atopic Dermatitis

NCT ID: NCT01702181

Last Updated: 2014-01-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

92 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2013-12-31

Brief Summary

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The purpose of this study is to investigate the pharmacokinetics and safety of OPA-15406 in adult subjects with atopic dermatitis

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Matching placebo.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Tacrolimus

Tacrolimus 0.1% ointment twice daily for 28 days.

Group Type ACTIVE_COMPARATOR

Tacrolimus

Intervention Type DRUG

0.1% concentration of tacrolimus.

OPA-15406

Group Type EXPERIMENTAL

OPA-15406

Intervention Type DRUG

0.3%, 1%, or 3% OPA-15406 topical ointment, applied twice daily for 28 days

Interventions

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OPA-15406

0.3%, 1%, or 3% OPA-15406 topical ointment, applied twice daily for 28 days

Intervention Type DRUG

Tacrolimus

0.1% concentration of tacrolimus.

Intervention Type DRUG

Placebo

Intervention Type DRUG

Other Intervention Names

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Protopic

Eligibility Criteria

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Inclusion Criteria

* Adult subjects 18-65 years of age
* Diagnosis of atopic dermatitis (AD)
* AD affecting at least 5% of total Body Surface Area (BSA) for Part 1 and at least 10% BSA for Part 2, not including face, neck, and head
* Have had a positive but inadequate response to one or more treatment course of standard AD therapy including topical steroids, UV light A, narrowband UV B, and UV light B.

Exclusion Criteria

-Use of systemic or topical therapy for contact or atopic dermatitis within 30 days of screening
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Mobile, Alabama, United States

Site Status

Hot Springs, Arizona, United States

Site Status

Irvine, California, United States

Site Status

Orange Park, Florida, United States

Site Status

Tampa, Florida, United States

Site Status

Carmel, Indiana, United States

Site Status

Berlin, New Jersey, United States

Site Status

High Point, North Carolina, United States

Site Status

Portland, Oregon, United States

Site Status

College Station, Texas, United States

Site Status

Dallas, Texas, United States

Site Status

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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271-12-204

Identifier Type: -

Identifier Source: org_study_id

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