Phase 2 Study of OPA-15406 Ointment in Pediatric Patients With Atopic Dermatitis

NCT ID: NCT03018691

Last Updated: 2020-07-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

73 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2017-06-30

Brief Summary

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To evaluate the safety, efficacy (dose response) and pharmacokinetics of 0.3% and 1% OPA-15406 when applied twice daily for 4 weeks in pediatric patients with atopic dermatitis.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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0.3% OPA-15406 Ointments

Subjects were treated with assigned 0.3% OPA-15406 ointment twice daily.

Group Type EXPERIMENTAL

OPA-15406

Intervention Type DRUG

1% OPA-15406 Ointments

Subjects were treated with assigned 1% OPA-15406 ointment twice daily.

Group Type EXPERIMENTAL

OPA-15406

Intervention Type DRUG

Placebo Ointments

Subjects were treated with assigned 0% OPA-15406 ointment twice daily.

Group Type PLACEBO_COMPARATOR

Placebos

Intervention Type DRUG

Interventions

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OPA-15406

Intervention Type DRUG

Placebos

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of atopic dermatitis based on the criteria of Hanifin and Rajka

Exclusion Criteria

* Subjects who have an atopic dermatitis or contact dermatitis flare-up defined as a sudden intensification of atopic dermatitis.
* Subjects who have an active viral skin infection.
* Subjects with a current or history of malignancy.
Minimum Eligible Age

2 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hiroaki Ono, Mr

Role: STUDY_DIRECTOR

Otsuka Pharmaceutical Co., Ltd.

Locations

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Hokkaido Region, , Japan

Site Status

Kanto Region, , Japan

Site Status

Kinki Region, , Japan

Site Status

Kyushu Region, , Japan

Site Status

Countries

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Japan

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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JapicCTI-173484

Identifier Type: OTHER

Identifier Source: secondary_id

271-102-00002

Identifier Type: -

Identifier Source: org_study_id

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