Comparison Trial of OPA-15406 Ointment in Adult Patients With Atopic DermatitisSyndrome

NCT ID: NCT03908970

Last Updated: 2021-01-25

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

364 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-25

Study Completion Date

2019-12-28

Brief Summary

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To demonstrate the superiority of IMP (1% OPA-15406 ointment or vehicle) to the vehicle when administered twice daily for 4 weeks using success rate in Investigator's Global Assessment (IGA) at Week 4 as the primary endpoint in adult patients with AD.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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1% OPA-15406

Twice daily

Group Type EXPERIMENTAL

1% OPA-15406

Intervention Type DRUG

Twice daily

Placebo

Twice daily

Group Type PLACEBO_COMPARATOR

Placebos

Intervention Type DRUG

Twice daily

Interventions

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1% OPA-15406

Twice daily

Intervention Type DRUG

Placebos

Twice daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of AD based on the Japanese Dermatological Association's criteria
* History of AD for at least 3 years
* Atopic dermatitis affecting more than or equal to 5%, to less than or equal to 40% of body surface area (BSA, excluding scalp) at the screening and baseline examinations
* IGA score of 2 or 3 at the screening and baseline examinations

Exclusion Criteria

* Subjects who have an AD or contact dermatitis flare-up defined as a rapid intensification of AD, within 28 days prior to the baseline examination
Minimum Eligible Age

15 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Osamu Sato

Role: STUDY_DIRECTOR

Otsuka Pharmaceutical Co., Ltd.

Locations

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Kitago Hifuka Clinic

Sapporo, , Japan

Site Status

Countries

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Japan

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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271-102-00007

Identifier Type: -

Identifier Source: org_study_id

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