The Impact of Hepatic Steatosis on Survival After Pancreaticoduodenectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-01

Study Completion Date

2025-01-01

Brief Summary

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We will use simple summaries, educational handouts, and discussions with doctors and nurses to explain this study. The study looks at patients with early-stage pancreatic cancer who undergo pancreaticoduodenectomy (Whipple surgery). We found that some patients develop fatty liver (non-alcoholic fatty liver disease, NAFLD) within six months after surgery, which can affect nutrition, blood sugar control, and long-term survival.

To help patients and families understand, we will:

1. Provide clear written information sheets about the purpose of the study and its findings.
2. Use diagrams or plain-language explanations of terms like "pancreatic exocrine function" and "fatty liver."
3. Share results with healthcare providers so they can guide patients in nutrition, enzyme replacement, diabetes monitoring, and follow-up care.
4. Offer contact information for the research team to answer questions.

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Detailed Description

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Conditions

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Nonalcoholic Fatty Liver Disease After Pancreaticoduodenectomy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Pancreaticoduodenectomy

Retrospective study evaluating postoperative NAFLD and metabolic outcomes in patients with stage I-II pancreatic cancer after PD.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adults with stage I-II pancreatic ductal adenocarcinoma.
* Underwent curative-intent pancreaticoduodenectomy (conventional or pylorus-preserving).
* Surgery between January 2015 and May 2023.
* Complete clinical and imaging data available.
* Survived at least 6 months postoperatively.