Prospective, Observational Study of Biomarkers in Liver Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To collect tumor tissue from patients with liver masses suspicious for primary liver cancer. The research biopsy will be used to identify biomarkers in future studies.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Identify Proteomic Biomarkers for Outcome Prediction of Locoregional Treatments for HCC

NCT04459468

Hepatocellular Carcinoma

COMPLETED

Feasibility of a Minimally Invasive Image-Guided Surgery System for Hepatic Procedures

NCT01237990

Liver Cancer

COMPLETED

Collection of Blood and Tissue Samples From Patients With Primary Liver Cancer.

NCT06899854

Hepatocellular Carcinoma (HCC) Cholangiocarcinoma

RECRUITING

Risk Factors and Molecular Genomics of U.S. Patients With Chronic Liver Disease and Hepatocellular Cancer

NCT01034865

Carcinoma, Hepatocellular

COMPLETED

A Prospective Study on the Application of Liquid Biopsy in the Surveillance of High-risk Population of HCC.

NCT06134973

Hepatocellular Carcinoma

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In this study patients are referred to the Department of Radiology for an image-guided (either CT or ultrasound) core needle biopsy of a liver mass suspicious for primary liver cancer as a part their clinical care. A written informed consent will be obtained for the clinical biopsy per standard protocol. Additional core biopsy of the liver mass will be performed for research purposes at the time of the clinical care biopsy. The additional research biopsy is not mandatory and is subject to a separate written informed consent, which will be obtained prior to the clinical biopsy.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hepatocellular Carcinoma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Primary Liver Cancer

Patients that have liver masses suspicious for primary liver cancer.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Liver mass suspicious for primary liver cancer with a diagnostic liver biopsy planned as a part of clinical care
2. Age ≥ 18 years.
3. ECOG performance status 0-2
4. Adequate organ and marrow function as defined below:

INR ≤ 1.5 platelets ≥ 70,000/mcl
5. Ability to understand and the willingness to sign a written informed consent
6. Target liver mass not subcapsular in nature as determined by the participating biopsy team
7. Child Pugh Turcotte score A or B

Exclusion Criteria

1. Previous treatment for HCC
2. Any contraindication for clinical-care liver biopsy, including anti-coagulation therapy that cannot be discontinued prior to biopsy or large volume ascites

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No