The Utility of Breath Biopsy as a Screening Tool for HCC
NCT ID: NCT04326491
Last Updated: 2022-05-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
18 participants
OBSERVATIONAL
2021-06-20
2022-05-16
Brief Summary
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Detailed Description
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The first group is patients with HCC secondary to cirrhosis. The second group will be patients with cirrhosis who are currently on the standard surveillance program with no HCC. Confirmation of the absence of HCC would have been ensured via a recent advanced imaging modality (dynamic CT scan or MRI) in the ongoing surveillance programme.
Participants will breathe into either a mouthpiece or collection tube then Breath samples will be analyzed via an analyzer to detect the volatile organic compounds (VOC) and quantitatively compare them
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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HCC
Participants are diagnosed with HCC on top of cirrhosis
Breath Biopsy
Analysis of breath samples to identify volatile molecules specific to HCC
Cirrhosis with no HCC
Participants are diagnosed with cirrhosis but have no HCC
Breath Biopsy
Analysis of breath samples to identify volatile molecules specific to HCC
Interventions
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Breath Biopsy
Analysis of breath samples to identify volatile molecules specific to HCC
Eligibility Criteria
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Inclusion Criteria
* Cirrhotic patients without HCC
Exclusion Criteria
* Patients who are not aware of the diagnosis
* Patients in whom the diagnosis of HCC is not clear and only suspected
* Patients with severe chronic obstructive pulmonary disease (COPD) or severe asthma.
18 Years
80 Years
ALL
No
Sponsors
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University of Aberdeen
OTHER
Responsible Party
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Principal Investigators
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Mohamed Bekheit, PhD
Role: PRINCIPAL_INVESTIGATOR
NHS Grampian
Locations
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Ashis Mukhopadhya
Aberdeen, , United Kingdom
Countries
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Other Identifiers
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1-085-18
Identifier Type: -
Identifier Source: org_study_id
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