To Evaluate the Efficacy and Safety of (18F-FCH) Comparing With (18F-FDG) for Detecting Hepatocellular Carcinoma

NCT ID: NCT02074202

Last Updated: 2014-02-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE3
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-02-28
• Study Completion Date: 2015-03-31

Brief Summary

Liver cancer is a major cause of death among patients of east or southeast asian descent, as well as other population groups, notably in central and west Africa. Diagnosis of liver cancer requires a combination of several imaging techniques and biopsies. Despite this, diagnosis can remain inconclusive or difficult to establish in patients at risk for liver cancer.

The purpose of this multi-center trial is to evaluate novel imaging methods developed to diagnose the most common form of liver cancer, hepatocellular carcinoma. We propose to use novel imaging probes that have been reported to bind to liver cancers but not benign liver lesions that can be confused with liver cancer. Two such imaging probes will be evaluated. 2-[18F]-fluoro-2-deoxy-D-glucose, called [18F]FDG, is a radioactive sugar that is widely used for cancer imaging with a device called positron emission tomography, or PET scans. We already know that [18F]FDG cannot detect some liver cancers that are slow growing. [18F]Fluorocholine ([18F]FCH), another molecule, has been recently reported to be highly effective at detecting liver cancer. In 2010, a French researcher reported 80-90% detection rate by using [18F]FCH alone or in combination with [18F]FDG.

We will compare [18F]FCH and [18F]FDG in evaluating 150 patients over a period of two years. The results will be correlated with those of biopsies and clinical follow-up.

This study will provide valuable data on whether these imaging agents can successfully differentiate malignant liver lesions from benign ones. It will also provide information about whether these imaging agents can successfully assess whether the cancer has spread outside the liver. It will provide data that will allow physicians to determine the optimal imaging protocol to properly diagnose liver cancer.

Conditions

Hepatocellular Carcinoma; Liver Disease

Keywords

18F fluorocholine; 18F fluorodeoxyglucose; hepatocellular carcinoma; PET CT scan

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: SINGLE

Study Groups

FCH PET/CT scan results

PET/CT scan results with FCH intravenous injection

Group Type: EXPERIMENTAL

18F- fluorocholine

Intervention Type: DRUG

To compare the diagnostic efficacy of FCH PET scan to FDG PET scan.

FDG PET/CT scan

PET/CT scan results with FDG intravenous injection

Group Type: ACTIVE_COMPARATOR

18F- fluorodeoxyglucose

Intervention Type: DRUG

To compare the diagnostic efficacy of FCH PET scan to FDG PET scan

Interventions

18F- fluorocholine

To compare the diagnostic efficacy of FCH PET scan to FDG PET scan.

Intervention Type: DRUG

18F- fluorodeoxyglucose

To compare the diagnostic efficacy of FCH PET scan to FDG PET scan

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Male or female, age ≥ 20 years old.

2. Patient who accepts to enter the study by signing written informed consent.

3. Patient with performance status ≤ 2 Eastern Cooperative Oncology Group (ECOG).

4. Patient with cirrhosis or chronic liver diseases suspected to have at least 1 hepatic nodule larger than 1 cm in diameter detected by conventional image (US, CT, MRI). Patient who has not yet received any therapy relevant to the aforementioned diagnosis. Hepatic nodule is defined as any one of the following conditions: suspicious hepatocellular carcinoma, benign tumor such as hemangioma, adenoma or focal nodular hyperplasia, metastatic lesions from other primary malignancy.

5. Female patient must take reliable contraception method(s) during the participation of the study.

Exclusion Criteria

1. Patient has serious allergic history or known allergy to 18F-FDG or 18F-FCH.

2. Patient has been diagnosed of multiple malignancies.

3. Female patient who is pregnant, lactating or planning to become pregnant during the study.

4. Patient has been participated in other investigational trials within 28 days prior to study enrollment.

5. Patient is unable to undergo PET/CT scan.

6. Subjects with active systemic infections, or medical conditions that may significantly affect action, adequate uptake and elimination of radiotracer.

7. Subject with conditions judged by the investigator as unsuitable for the study.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Kai-Yuan Tzen, MD

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

National Taiwan University Hospital

Taipei, , Taiwan

Countries

Taiwan

Central Contacts

Kai-Yuan Tzen, MD

Role: CONTACT

Phone: 886-2-23123456

Email: tzenky@ntuh.gov.tw

Pan-Fu Kao, MD

Role: CONTACT

Phone: 886-9-88334304

Email: pfkao@csmu.edu.tw

Facility Contacts

Kai-Yuan Tzen, MD

Role: primary

Pan-Fu Kao, MD

Role: backup

Other Identifiers

201111019MIB

Identifier Type: -

Identifier Source: org_study_id