Pretreatment Lymphocyte Monocyte Ratio on Outcome HCC Patients
NCT ID: NCT03869151
Last Updated: 2019-04-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1 participants
OBSERVATIONAL
2019-04-05
2020-03-31
Brief Summary
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Detailed Description
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Tumor-infiltrating lymphocytes, as representative component of the immune microenvironment ,are implicated in several stages of Heatocellular carcinoma progression, and Tumor-infiltrating lymphocytes phenotypes may be a predictor for favorable prognosis.
Conversely, low lymphocyte counts might result in an insufficient immunological reaction, which lead to inferior survival in multiple cancers.
Monocytes infiltrating tumor tissue are also involved in Heatocellular carcinoma development and progression. Activated monocytes in Heatocellular carcinoma micro environments can trigger and polarize T-cell responses and facilitate inflammation-induced tumor development.
Tumor-associated macrophages are derived from circulating monocytes. Tumor-associated macrophages can accelerate Heatocellular carcinoma cell proliferation,tumor-associated angiogenesis, and metastasis. Several studies showed that high infiltration of Tumor-associated macrophages predicted decreased survival in various cancers.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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CBC
lymphocyte and monocyte count
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients with heart failure
20 Years
80 Years
ALL
No
Sponsors
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Amany Aboalenen Amin
OTHER
Responsible Party
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Amany Aboalenen Amin
Principal Investigator
Principal Investigators
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taha mahran, MD
Role: STUDY_CHAIR
Assiut University
ola abdelfatah, MD
Role: STUDY_CHAIR
Assiut University
aml ebraheem, MD
Role: STUDY_DIRECTOR
Assiut University
amany amin, master
Role: PRINCIPAL_INVESTIGATOR
Assiut University
Central Contacts
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Other Identifiers
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17200000
Identifier Type: -
Identifier Source: org_study_id
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