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Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure

NCT ID: NCT04310787

Last Updated: 2024-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-15

Study Completion Date

2024-12-31

Brief Summary

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This study is to investigate the long-term outcomes and prognostic risk factors in patients recovered from hepatitis B virus related acute on-chronic liver failure.

Detailed Description

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Chronic acute liver failure (ACLF) is a systemic multi-organ failure driven by acute liver injury in the basis of chronic liver disease. The main cause of chronic acute liver failure in China is hepatitis b virus infection.Previous studies on the prognosis of acute on-chronic liver failure mainly focused on the short-term survival rate and the follow-up time was relatively short, while the study on the long-term prognosis of patients with spontaneous recovery of chronic acute liver failure was still lack-ing. Thus,this study mainly retrospectively analyzed the clinical data of patients with chronic hepatitis b related acute liver failure admitted to the department of infectious diseases, the third affiliated hospital of sun yat-sen university, and con-ducted telephone follow-up survey to analyze the long-term prognosis of patients with chronic hepatitis b related acute on-chronic liver failure.

Conditions

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Hepatitis B Acute-On-Chronic Liver Failure

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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HBV-ACLF

To investigate the clinical events and prognosis of patients with hepatitis b associated acute on-chronic liver failure

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age from 18 to 65 years old;
* The diagnosis consistent with hepatitis b associated chronic acute liver failure；
* After hospitalization, the survival time \> 90 days；
* The inpatient clinical data are complete.

Exclusion Criteria

* Human immunodeficiency virus infection or congenital immune deficiency diseases;
* Liver cancer and other tumors, autoimmune liver disease, genetic and metabolic liver disease, or other serious diseases that significantly affect patient survival;
* Other conditions that the researchers judged not appropriate for inclusion.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Third Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role lead

Responsible Party

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Liang Peng

Professer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Liang Peng, Doctor

Role: PRINCIPAL_INVESTIGATOR

Third Affiliated Hospital, Sun Yat-Sen University

Locations

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Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lu Wang, Doctor

Role: CONTACT

[email protected]
+8618814369232

Liang Peng, Doctor

Role: CONTACT

[email protected]
+8613533978874

Facility Contacts

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Liang Peng, Doctor

Role: primary

[email protected]
+8613533978874

Other Identifiers

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PL12

Identifier Type: -

Identifier Source: org_study_id