Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine Surgery: A Randomized, Double-blind, Controlled Trial
NCT ID: NCT07180940
Last Updated: 2025-09-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
PHASE4
150 participants
INTERVENTIONAL
2025-09-01
2026-12-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries
NCT05843344
Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block
NCT06231979
Dexmedetomidine Combined With Bupivacaine for Erector Spinae Plane Block
NCT05590234
Erector Spinae Block With Ropivacaine and Dexmedetomidine on Opioid Consumption After Lumar Spine Surgeries
NCT05664542
Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery
NCT05871073
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The main goal is to see how much opioid pain medicine patients need during the first 24 and 48 hours after surgery. Other things we will look at include how strong the pain is, how soon pain relief is necessary, if there are any side effects like nausea or low blood pressure, and if there are any complications related to the block.
This study will help doctors choose the best option to manage pain after spine surgery while reducing the need for opioids and their side effects.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Control group
Bilateral ESPB (2 x 20ml 0.2% ropivacaine with 1ml 0.9% NaCl)
0.9%NaCl
2 x 20ml 0.2% ropivacaine with 2ml of 0.9% NaCl
Dexamethasone group
Bilateral ESPB (2 x 20ml 0.2% ropivacaine with 2mg dexamethasone)
Dexamethasone 4mg
2 x 20ml 0.2% ropivacaine with 2mg of dexamethasone
Dexmedetomidine group
Bilateral ESPB (2 x 20ml 0.2% ropivacaine with 25ug dexmedetomidine)
Dexmedetomidine
2 x 20ml 0.2% ropivacaine with 25ug Dexmedetomidine
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
0.9%NaCl
2 x 20ml 0.2% ropivacaine with 2ml of 0.9% NaCl
Dexamethasone 4mg
2 x 20ml 0.2% ropivacaine with 2mg of dexamethasone
Dexmedetomidine
2 x 20ml 0.2% ropivacaine with 25ug Dexmedetomidine
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Scheduled for elective lumbar spine surgery (e.g., decompression or fusion) via posterior approach
* American Society of Anesthesiologists (ASA) physical status I-III
* Body weight ≥ 50 kg
* Ability to provide written informed consent
* Expected postoperative hospitalization of at least 48 hours
Exclusion Criteria
* Infection at or near the site of block placement
* Coagulation disorders or current use of anticoagulant therapy (not discontinued per guidelines)
* Chronic opioid use or opioid dependence
* Neurological or psychiatric disorders interfering with pain assessment
* Diabetes mellitus with poorly controlled glycemia (e.g., HbA1c \> 8%)
* Severe hepatic or renal dysfunction
* Body mass index (BMI) \> 40 kg/m²
* Pregnancy or breastfeeding
* Refusal or inability to cooperate with the study protocol
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Poznan University of Medical Sciences
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Poznan University of Medical Sciences
Poznan, , Poland
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
01/2025
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.