Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth
NCT ID: NCT07170098
Last Updated: 2026-01-12
Study Results
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Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2025-08-10
2025-10-31
Brief Summary
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Detailed Description
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Eighty medically healthy adult patients (18-65 years) were randomly assigned to four groups. Group 1 underwent final irrigation with EDDY; Group 2 with EA; Group 3 with EDDY followed by laser irradiation; Group 4 with EA followed by laser irradiation. All procedures were completed in a single visit. PP was measured using a 0-10 numerical rating scale at 8, 24, 48 hours, and day 7. Analgesic consumption was also recorded.
Statistical analysis showed no significant differences among groups for age, sex, PP scores, or analgesic intake. None of the patients experienced severe pain or swelling requiring emergency intervention. The findings suggest that both EDDY and EA sonic irrigation systems, with or without adjunctive 980-nm diode laser disinfection, do not significantly affect post-operative pain or analgesic use following single-visit root canal treatment of asymptomatic apical periodontitis.
These results provide insight into the effectiveness of sonic irrigation activation and laser disinfection in routine endodontic practice, indicating that alternative techniques may be explored to optimize patient comfort and treatment outcomes.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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EDDY sonic irrigation
Final irrigation activation was performed using the EDDY sonic system with 5.25% NaOCl for three 20-second cycles, followed by 17% EDTA for 30 seconds and 5 mL saline. No laser irradiation was applied.
EDDY sonic irrigation system
Sonic activation of irrigating solutions during endodontic treatment.
EndoActivator (EA) sonic irrigation
Final irrigation activation was performed using the EndoActivator (EA) medium tip with 5.25% NaOCl for three 20-second cycles, followed by 17% EDTA for 30 seconds and 5 mL saline. No laser irradiation was applied.
EndoActivator (EA) sonic irrigation system
Sonic activation of irrigating solutions during endodontic treatment.
EDDY sonic irrigation + 980-nm diode laser
Final irrigation activation was performed using the EDDY sonic system as in Arm 1, followed by adjunctive 980-nm diode laser irradiation (1.2 W, 50 Hz, 12 J per cycle, 4 cycles, pulsed mode).
EDDY sonic irrigation system
Sonic activation of irrigating solutions during endodontic treatment.
980-nm diode laser
Diode laser irradiation during endodontic treatment.
EndoActivator (EA) sonic irrigation + 980-nm diode laser
Final irrigation activation was performed using the EndoActivator (EA) system as in Arm 2, followed by adjunctive 980-nm diode laser irradiation (1.2 W, 50 Hz, 12 J per cycle, 4 cycles, pulsed mode).
EndoActivator (EA) sonic irrigation system
Sonic activation of irrigating solutions during endodontic treatment.
980-nm diode laser
Diode laser irradiation during endodontic treatment.
Interventions
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EDDY sonic irrigation system
Sonic activation of irrigating solutions during endodontic treatment.
EndoActivator (EA) sonic irrigation system
Sonic activation of irrigating solutions during endodontic treatment.
980-nm diode laser
Diode laser irradiation during endodontic treatment.
Eligibility Criteria
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Inclusion Criteria
* Patients diagnosed with asymptomatic apical periodontitis in permanent single-rooted teeth with closed apices and radiographic PAI score of 3 or 4
* Healthy periodontal conditions
Exclusion Criteria
* Patients with systemic disorders
* Teeth with open apex, prosthetic restorations, mobility \> grade I, periodontal pocket depth \> 4 mm, non-restorable condition, calcified root canals, resorption, traumatic occlusion, or history of previous endodontic treatment
* Patients who had taken analgesics within 12 hours prior to intervention
* Patients who had received antibiotic therapy within the past month
18 Years
65 Years
ALL
Yes
Sponsors
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Biruni University
OTHER
Responsible Party
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Sema Sönmez Kaplan
Associate Professor
Locations
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Biruni University
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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BİRUNİ-BAP-01-2023-01-05
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
BİRUNİ-BAP-01-2023-01-05
Identifier Type: -
Identifier Source: org_study_id
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