Two Types of PRF Membranes in Management of Dehiscence Defect in Posterior Mandible

NCT ID: NCT07164417

Last Updated: 2025-09-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-10-12
• Study Completion Date: 2025-01-20

Brief Summary

Background: Placement of implants in an atrophic posterior ridge is a challenge for so many clinicians. The success of dental implants depends on the volume of alveolar bone available to provide stability. Bone grafting using xenograft with PRF and e-PRF as a membrane has shown promising results in both bone healing and defect reconstruction. Aim of the study: to evaluate the effect of Platelet-rich fibrin (PRF) and Extended Platelet-rich fibrin (e-PRF) as a membrane with xenograft to increase the width of ridge in posterior mandible with simultaneous implant placement.

Conditions

Atrophic Mandible

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

PRF

Group Type: ACTIVE_COMPARATOR

PRF membrane will be used with xenograft simultaneously with implant placement

Intervention Type: OTHER

Peripheral blood is collected in 9-10 mL additive-free tubes and centrifuged horizontally at 700-2000 g for 8 minutes.

e-PRF

Group Type: EXPERIMENTAL

e-PRF membrane will be used with xenograft simultaneously with implant placement.

Intervention Type: OTHER

Peripheral blood is collected in plain tubes and centrifuged (700-2000 g, 8 min) to separate plasma from red cells. The first 2-4 mL of platelet-poor plasma (PPP) is withdrawn and heated at 75 °C for 10 minutes to form albumin gel, then cooled for 1-2 minutes. Meanwhile, the remaining blood fractions (buffy coat, liquid PRF, red cells) are kept cooled to prevent premature clotting.

Interventions

e-PRF membrane will be used with xenograft simultaneously with implant placement.

Peripheral blood is collected in plain tubes and centrifuged (700-2000 g, 8 min) to separate plasma from red cells. The first 2-4 mL of platelet-poor plasma (PPP) is withdrawn and heated at 75 °C for 10 minutes to form albumin gel, then cooled for 1-2 minutes. Meanwhile, the remaining blood fractions (buffy coat, liquid PRF, red cells) are kept cooled to prevent premature clotting.

Intervention Type: OTHER

PRF membrane will be used with xenograft simultaneously with implant placement

Peripheral blood is collected in 9-10 mL additive-free tubes and centrifuged horizontally at 700-2000 g for 8 minutes.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient with one or more missing posterior mandibular teeth.
• Patient with atrophic posterior mandible with residual ridge width in the range of 4 to 6mm.
• Patient with good oral hygiene and acceptable inter-arch space less than or equal to the restoration

Exclusion Criteria

• The patient underwent alveolar ridge reconstruction in the same area.
• Patients with immune diseases, uncontrolled hypertension, and uncontrolled diabetes.
• Patient with any pathological condition at the site of surgery.
• Heavy smoker, alcohol abuse, parafunctional habits.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Alexandria University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt

Alexandria, Azarita, Egypt

Countries

Egypt

Other Identifiers

0936-06/2024

Identifier Type: -

Identifier Source: org_study_id