Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients

NCT ID: NCT07164326

Last Updated: 2025-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-15

Study Completion Date

2026-12-15

Brief Summary

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Dexmedetomidine nebulization in sever preeclamptic patients

Detailed Description

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Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.

Conditions

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Pressor Response

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Dexmedetomidine

Nebulization of dexmedetomidine

Group Type EXPERIMENTAL

Dexmedetomidine

Intervention Type DRUG

Nebulization of dexmedetomidine

Saline

Nebulization of saline

Group Type PLACEBO_COMPARATOR

Saline

Intervention Type DRUG

Nebulization of normal saline

Interventions

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Dexmedetomidine

Nebulization of dexmedetomidine

Intervention Type DRUG

Saline

Nebulization of normal saline

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
* ASA II, III

Exclusion Criteria

* sever obesity (BMI ≥ 40)
* Cardiac patients
* History of diabetes mellitus
* Renal dysfunction (elevated serum creatinine \> 2mg\\dl)
* hepatic dysfunction (elevated hepatic enzyme three times above normal)
* History to hypersensitivity to the tested drug.
* Emergency surgery
* Known fetal anomalies
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Sayed Hussein Hassan

Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Mohamed S. Hussein

Role: CONTACT

+201028586836

Fatma Nabil

Role: CONTACT

Other Identifiers

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Dexmedetomidine nebulization

Identifier Type: -

Identifier Source: org_study_id

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