Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients
NCT ID: NCT03391609
Last Updated: 2019-02-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
30 participants
INTERVENTIONAL
2017-06-18
2019-01-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Study Groups
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control group
Caesarian section will be performed under standard general anesthesia plus pre and intra operative saline infusion (placebo) in the same rate as dexmedetomedine starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
placebo infusion
Caesarian section will be performed under standard general anesthesia plus pre and intra operative saline infusion (placebo) in the same rate as dexmedetomedine starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
Dex. group
Caesarian section will be performed under standard general anesthesia plus pre and intra operative Dexmedetomidine infusion in a dose of 0.5mic/kg/hour starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
Dexmedetomidine infusion
Caesarian section will be performed under standard general anesthesia plus pre and intra operative Dexmedetomidine infusion in a dose of 0.5mic/kg/hour starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
Interventions
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placebo infusion
Caesarian section will be performed under standard general anesthesia plus pre and intra operative saline infusion (placebo) in the same rate as dexmedetomedine starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
Dexmedetomidine infusion
Caesarian section will be performed under standard general anesthesia plus pre and intra operative Dexmedetomidine infusion in a dose of 0.5mic/kg/hour starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
Eligibility Criteria
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Inclusion Criteria
* have mild preeclampsia ( Pre-eclamptic patients will be defined as having hypertension \[systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP)≥90 mmHg\] accompanied by proteinuria first detected after 20 weeks of gestation).
* Proteinuria is defined as at least 300 mg protein in 24 h urine collection \[or ≥1+ dipstick (30 mg/dl) in a single urine sample\] ).
* American Society of Anesthesiologists (ASA) physical status of II or III.
* age between 19 and 40 years
Exclusion Criteria
* pre-existing neurological disease or psychic patients.
* history of cardiac and respiratory system failure.
* co-existing significant renal or liver disease.
19 Years
40 Years
FEMALE
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Ahmad Mohammad Abd El-Rahman
lecturer
Locations
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South Egypt Cancer Institute
Asyut, , Egypt
Countries
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Other Identifiers
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144
Identifier Type: -
Identifier Source: org_study_id
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