Digital Cognitive Behavioral Therapy for Chinese Adolescents With Depressive Symptoms（CADS-D )
NCT ID: NCT07163013
Last Updated: 2026-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2025-05-12
2026-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Digital cognitive behavioral therapy Group
Participants in the intervention group are required to complete two module a week and all modules were be delivered in 6 weeks after the program starts.
Digital cognitive behavioral therapy(DCBT)
Moca is a mobile application designed to deliver structural CBT for adolescents with mood problems. Moca provides six-twelve guided sessions with an estimated proceeding duration of 25-45min each, developed to be processed weekly. The content of each session includes the introduction of the core concepts and principles of CBT, psychological counseling dialogue, skill exercises, and homework. Content presentation forms include text, animation, audio, comics, etc. At the end of each module, the participants will be asked to submit homework that will ask them to apply their learned skills to nursing or daily life situations that they personally perceive as stressful. Participants can review the completed sessions and record their mood status during the intervention period.
Regular mental health curriculum Group
The participants of control group are allocated to regular mental health curriculum provided by school staff for 6 weeks.
Regular mental health curriculum
The content of regular mental health curriculum includes mental health education lecture. Few lectures address the knowledge and skills involved in CBT in such education lecture.
Interventions
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Digital cognitive behavioral therapy(DCBT)
Moca is a mobile application designed to deliver structural CBT for adolescents with mood problems. Moca provides six-twelve guided sessions with an estimated proceeding duration of 25-45min each, developed to be processed weekly. The content of each session includes the introduction of the core concepts and principles of CBT, psychological counseling dialogue, skill exercises, and homework. Content presentation forms include text, animation, audio, comics, etc. At the end of each module, the participants will be asked to submit homework that will ask them to apply their learned skills to nursing or daily life situations that they personally perceive as stressful. Participants can review the completed sessions and record their mood status during the intervention period.
Regular mental health curriculum
The content of regular mental health curriculum includes mental health education lecture. Few lectures address the knowledge and skills involved in CBT in such education lecture.
Eligibility Criteria
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Inclusion Criteria
2. Scored 28 or higher on the children's depression rating scale-revised (CDRS-R);
3. Have the ability to read and write in Chinese;
4. Participant and at least one of their guardians provided written consent;
5. Have access to mobile phone and internet.
Exclusion Criteria
2. Scored 5 or higher on item 13 (suicidal ideation) on CDRS-R;
3. Participants who met diagnosis of other mental disorder except depression;
4. Severe physical illnesses or other physical disabilities that prevented the use of DCBT;
5. Within the past three months or currently undergoing any antidepressant treatment, including medication therapy, psychotherapy, and physical therapy;
6. Unavailability to follow up months after intervention.
12 Years
18 Years
ALL
No
Sponsors
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First Affiliated Hospital of Chongqing Medical University
OTHER
Responsible Party
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Xinyu Zhou
Professor
Locations
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, , China
Countries
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Central Contacts
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Facility Contacts
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References
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Barker MM, Beresford B, Bland M, Fraser LK. Prevalence and Incidence of Anxiety and Depression Among Children, Adolescents, and Young Adults With Life-Limiting Conditions: A Systematic Review and Meta-analysis. JAMA Pediatr. 2019 Sep 1;173(9):835-844. doi: 10.1001/jamapediatrics.2019.1712.
Janssens KA, Rosmalen JG, Ormel J, van Oort FV, Oldehinkel AJ. Anxiety and depression are risk factors rather than consequences of functional somatic symptoms in a general population of adolescents: the TRAILS study. J Child Psychol Psychiatry. 2010 Mar;51(3):304-12. doi: 10.1111/j.1469-7610.2009.02174.x. Epub 2009 Sep 28.
Pettit JW, Lewinsohn PM, Roberts RE, Seeley JR, Monteith L. The long-term course of depression: development of an empirical index and identification of early adult outcomes. Psychol Med. 2009 Mar;39(3):403-12. doi: 10.1017/S0033291708003851. Epub 2008 Jul 8.
Weissman MM, Wolk S, Goldstein RB, Moreau D, Adams P, Greenwald S, Klier CM, Ryan ND, Dahl RE, Wickramaratne P. Depressed adolescents grown up. JAMA. 1999 May 12;281(18):1707-13. doi: 10.1001/jama.281.18.1707.
O'Keeffe S, Martin P, Goodyer IM, Kelvin R, Dubicka B; IMPACT Consortium; Midgley N. Prognostic Implications for Adolescents With Depression Who Drop Out of Psychological Treatment During a Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2019 Oct;58(10):983-992. doi: 10.1016/j.jaac.2018.11.019. Epub 2019 Apr 1.
Thapar A, Collishaw S, Pine DS, Thapar AK. Depression in adolescence. Lancet. 2012 Mar 17;379(9820):1056-67. doi: 10.1016/S0140-6736(11)60871-4. Epub 2012 Feb 2.
Davey CG, Chanen AM, Hetrick SE, Cotton SM, Ratheesh A, Amminger GP, Koutsogiannis J, Phelan M, Mullen E, Harrison BJ, Rice S, Parker AG, Dean OM, Weller A, Kerr M, Quinn AL, Catania L, Kazantzis N, McGorry PD, Berk M. The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial. Lancet Psychiatry. 2019 Sep;6(9):735-744. doi: 10.1016/S2215-0366(19)30215-9. Epub 2019 Jul 29.
Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P. Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis. Lancet Psychiatry. 2020 Jul;7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1.
Fitzpatrick KK, Darcy A, Vierhile M. Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial. JMIR Ment Health. 2017 Jun 6;4(2):e19. doi: 10.2196/mental.7785.
Rushton J, Bruckman D, Kelleher K. Primary care referral of children with psychosocial problems. Arch Pediatr Adolesc Med. 2002 Jun;156(6):592-8. doi: 10.1001/archpedi.156.6.592.
Ritterband LM, Andersson G, Christensen HM, Carlbring P, Cuijpers P. Directions for the International Society for Research on Internet Interventions (ISRII). J Med Internet Res. 2006 Sep 29;8(3):e23. doi: 10.2196/jmir.8.3.e23.
Imamura K, Kawakami N, Furukawa TA, Matsuyama Y, Shimazu A, Umanodan R, Kawakami S, Kasai K. Does Internet-based cognitive behavioral therapy (iCBT) prevent major depressive episode for workers? A 12-month follow-up of a randomized controlled trial. Psychol Med. 2015 Jul;45(9):1907-17. doi: 10.1017/S0033291714003006. Epub 2015 Jan 7.
Hallgren M, Helgadottir B, Herring MP, Zeebari Z, Lindefors N, Kaldo V, Ojehagen A, Forsell Y. Exercise and internet-based cognitive-behavioural therapy for depression: multicentre randomised controlled trial with 12-month follow-up. Br J Psychiatry. 2016 Nov;209(5):414-420. doi: 10.1192/bjp.bp.115.177576. Epub 2016 Sep 8.
Thase ME, Wright JH, Eells TD, Barrett MS, Wisniewski SR, Balasubramani GK, McCrone P, Brown GK. Improving the Efficiency of Psychotherapy for Depression: Computer-Assisted Versus Standard CBT. Am J Psychiatry. 2018 Mar 1;175(3):242-250. doi: 10.1176/appi.ajp.2017.17010089. Epub 2017 Oct 3.
Kaltenthaler E, Parry G, Beverley C, Ferriter M. Computerised cognitive-behavioural therapy for depression: systematic review. Br J Psychiatry. 2008 Sep;193(3):181-4. doi: 10.1192/bjp.bp.106.025981.
Merry SN, Stasiak K, Shepherd M, Frampton C, Fleming T, Lucassen MF. The effectiveness of SPARX, a computerised self help intervention for adolescents seeking help for depression: randomised controlled non-inferiority trial. BMJ. 2012 Apr 18;344:e2598. doi: 10.1136/bmj.e2598.
Fleming T, Lucassen M, Stasiak K, Sutcliffe K, Merry S. Technology Matters: SPARX - computerised cognitive behavioural therapy for adolescent depression in a game format. Child Adolesc Ment Health. 2021 Feb;26(1):92-94. doi: 10.1111/camh.12444. Epub 2021 Jan 4.
Ivlev I, Beil TL, Haynes JS, Patnode CD. Rapid Evidence Review of Digital Cognitive-Behavioral Therapy for Adolescents With Depression. J Adolesc Health. 2022 Jul;71(1):14-29. doi: 10.1016/j.jadohealth.2022.01.220. Epub 2022 Mar 4.
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Srivastava P, Mehta M, Sagar R, Ambekar A. Smartteen- a computer assisted cognitive behavior therapy for Indian adolescents with depression- a pilot study. Asian J Psychiatr. 2020 Apr;50:101970. doi: 10.1016/j.ajp.2020.101970. Epub 2020 Feb 19.
Other Identifiers
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1stChongqingMu2
Identifier Type: -
Identifier Source: org_study_id
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