Peripheral Nerve Activation Sensitivity

NCT ID: NCT07160413

Last Updated: 2025-09-12

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-09-01
• Study Completion Date: 2026-12-31

Brief Summary

Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.

Conditions

Nerve Excitation Sensitivity

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Stimulated

Group Type: EXPERIMENTAL

Electric and electromagnetic stimulation

Intervention Type: DEVICE

Application of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes

Interventions

Electric and electromagnetic stimulation

Application of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Person aged > 18 years
• Signed informed consent
• Healthy
• Willingness and ability to adhere to study procedures

Exclusion Criteria

• Known hypersensitivity to electric or electromagnetic stimulation
• Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants
• Neurological or neuromuscular disorders or conditions
• History of seizures or epilepsy
• Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics)
• Pregnancy or breastfeeding
• Surgical intervention of the arm within the last 4 weeks
• Allergy to adhesives or ultrasound gel components (e.g., polyethylene glycols)
• Skin lesions, infections, or strictures in the arm region
• Tattoos on the stimulated (right) arm and hand, or in any area likely to be captured in video recordings
• Inability to follow study procedures (e.g., due to language barrier, psychological disorders, dementia)
• Participant deprived of liberty by administrative or judicial decision or under legal guardianship

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Bern University of Applied Sciences

OTHER

Sponsor Role: collaborator

Swiss Paraplegic Research, Nottwil

NETWORK

Sponsor Role: collaborator

Thomas Niederhauser

OTHER

Sponsor Role: lead

Responsible Party

Thomas Niederhauser

Prof. Dr.

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Institute for Human Centered Engineering HuCE

Biel, Biel, Switzerland

Site Status: RECRUITING

Countries

Switzerland

Central Contacts

Thomas Niederhauser, PhD

Role: CONTACT

thomas.niederhauser@bfh.ch

+41 32 321 67 63

Facility Contacts

Thomas Niederhauser, Prof. Dr.

Role: primary

thomas.niederhauser@bfh.ch

+41 32 321 67 63

Other Identifiers

108.018 IP-LS

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2025-00776

Identifier Type: -

Identifier Source: org_study_id