Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain

NCT ID: NCT03037684

Last Updated: 2025-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-03-27

Study Completion Date

2025-12-31

Brief Summary

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The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.

Detailed Description

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Sinus-like electrical stimulation may depolarize unmyelinated skin nociceptors involving NaV1.7 channels. In this case electrical stimulation may provoke pain already with very low currency intensity which normally not provoke pain in healthy subjects. This may be predictive for pain relief due to the sodium channel blocker lidocaine 5% patch.

The study will characterize pain states in peripheral neuropathic pain as well as within the painful scar in chronic postoperative pain with regard to the involvement of NaV1.7 channels.

In addition, the pain site in chronic postoperative pain (scar) will be characterized by laser-evoked potentials (LEP) and quantitative sensory testing (QST).

Pain related questionnaires will be obtained.

Conditions

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Neuropathy;Peripheral

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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chronic pain

individuals suffering from chronic pain

neurophysiology

Intervention Type DIAGNOSTIC_TEST

electrophysiologic measurements of peripheral nerves

neuropathic pain

individuals suffering from neuropathic pain

neurophysiology

Intervention Type DIAGNOSTIC_TEST

electrophysiologic measurements of peripheral nerves

Interventions

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neurophysiology

electrophysiologic measurements of peripheral nerves

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Group (1) patients with neuropathic pain
* Group (2) patients with chronic postoperative pain

Exclusion Criteria

* severe psychiatric disorder requiring hospitalisation in the past
* any neurological disease other than the pain diagnosis
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Swiss Paraplegic Research, Nottwil

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre for Pain Medicine

Nottwil, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Gunther Landmann, MD

Role: CONTACT

+4141939 ext. 4925

Facility Contacts

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Gunther Landmann, MD

Role: primary

+4141939 ext. 4925

References

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Rolke R, Baron R, Maier C, Tolle TR, Treede -DR, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006 Aug;123(3):231-243. doi: 10.1016/j.pain.2006.01.041. Epub 2006 May 11.

Reference Type BACKGROUND
PMID: 16697110 (View on PubMed)

Other Identifiers

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2016-15

Identifier Type: -

Identifier Source: org_study_id

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