Kaempferol Gel , Alkaline Phosphatase Activity , Bone Density Around Dental Implants
NCT ID: NCT07156799
Last Updated: 2025-09-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2023-06-05
2024-12-07
Brief Summary
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Detailed Description
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The study measured alkaline phosphatase (ALP) activity in peri-implant crevicular fluid at 1, 2, and 4 weeks, and bone density using CBCT at baseline and 6 months. Results showed that Kaempferol significantly boosted ALP activity at 2 and 4 weeks, suggesting faster bone remodeling. At 6 months, bone density improved in both groups, but the Kaempferol group showed a greater increase (40.73% vs. 33.21%).
In conclusion, Kaempferol gel enhanced early bone healing and improved bone density around implants, indicating its potential as a cost-effective, biocompatible adjunct to accelerate osseointegration and possibly allow earlier implant loading, particularly in patients with poor bone quality.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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test group
kaempferol gel application and implant placement
Kaempferol Gel
Local topical application of Kaempferol gel into the implant site during one-stage delayed implant placement to enhance peri-implant bone healing and osseointegration.
control group
implant placement with out application of kaempferol
No interventions assigned to this group
Interventions
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Kaempferol Gel
Local topical application of Kaempferol gel into the implant site during one-stage delayed implant placement to enhance peri-implant bone healing and osseointegration.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
50 Years
ALL
Yes
Sponsors
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Al-Azhar University
OTHER
Responsible Party
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Nora Abdelgawad Mohamed
Associate Professor of Oral Medicine, Periodontology and Diagnosis, Faculty of Dental Medicine for girls, Al -Azhar University, Cairo, Egypt
Principal Investigators
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Dr. Nora Abdelgawad
Role: PRINCIPAL_INVESTIGATOR
Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt
Locations
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Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Cairo Governorate, Egypt
Countries
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Other Identifiers
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OMPDR-103-2F
Identifier Type: -
Identifier Source: org_study_id
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