Ophthalmic Diseases and AI: an RCT Study

NCT ID: NCT07154680

Last Updated: 2025-09-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-08-15

Study Completion Date

2025-01-30

Brief Summary

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Ophthalmic diseases are a major category of conditions affecting visual health, including but not limited to cataracts, glaucoma, retinal and choroidal diseases, and refractive errors (such as myopia, hyperopia, and astigmatism). With the advancement of technology, artificial intelligence (AI) is being increasingly applied in the field of ophthalmology. This clinical trial aims to evaluate the potential of large language models (LLMs) in ophthalmology.

The main questions to be addressed are:

1. Assessing the effectiveness of large language models (LLMs) in the diagnosis and treatment of ophthalmic diseases: Through randomized controlled trials (RCTs), evaluate the diagnostic and treatment effectiveness of LLMs in the field of ophthalmic diseases, exploring their potential to improve the quality and efficiency of ophthalmic care.
2. Investigating the role of LLMs in medical consultations: Explore the role and effectiveness of LLMs in medical consultations for ophthalmic diseases, including their ability to provide medical advice, explain diagnostic results, and help patients understand treatment plans.
3. Examining the ability of LLMs to adhere to ethical standards: Study how to ensure that LLMs comply with ethical standards and moral principles in ophthalmic medical consultations, safeguarding patient privacy and rights.
4. Providing new technological support for the field of ophthalmology: Through research on the application of LLMs in ophthalmic diseases, offer new technological support and innovations to enhance the quality and efficiency of ophthalmic care.
5. Exploring the differences between LLMs and ophthalmologists: By utilizing multiple large language models, compare the differences between LLMs and ophthalmologists in diagnostic outcomes, case analysis processes, and patient experiences during diagnosis and treatment.
6. Evaluating the effectiveness of LLMs in ophthalmic diseases: Collect patient complaints, fundus images, doctors' diagnoses, and diagnosis times from offline doctor consultations, as well as gather AI-generated medical advice, diagnostic efficiency, and diagnostic accuracy online. Ultimately, conduct comprehensive data analysis to determine the feasibility and effectiveness of LLMs in diagnosing and treating ophthalmic diseases.

Detailed Description

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Conditions

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Eye Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Large Language Model Diagnostics Group

GPT-4o mini;Claude 3 Haiku;Gemini 1.5 Flash;Llama 3.1 7OB;GPT-4o;Claude 3.5 Sonnet;Gemini 1.5 Pro;Llama 3.1 4O5B

Intervention Type DIAGNOSTIC_TEST

Input all the patient's information into the large language model and process it using a pre-defined prompt.

Large Language Model Medical Assistance Group

GPT-4o mini;Claude 3 Haiku;Gemini 1.5 Flash;Llama 3.1 7OB;GPT-4o;Claude 3.5 Sonnet;Gemini 1.5 Pro;Llama 3.1 4O5B

Intervention Type DIAGNOSTIC_TEST

Input all the patient's information into the large language model and process it using a pre-defined prompt.

Large Language Model Medical Explanation Team

GPT-4o mini;Claude 3 Haiku;Gemini 1.5 Flash;Llama 3.1 7OB;GPT-4o;Claude 3.5 Sonnet;Gemini 1.5 Pro;Llama 3.1 4O5B

Intervention Type DIAGNOSTIC_TEST

Input all the patient's information into the large language model and process it using a pre-defined prompt.

Interventions

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GPT-4o mini;Claude 3 Haiku;Gemini 1.5 Flash;Llama 3.1 7OB;GPT-4o;Claude 3.5 Sonnet;Gemini 1.5 Pro;Llama 3.1 4O5B

Input all the patient's information into the large language model and process it using a pre-defined prompt.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* There are patient complaints

Exclusion Criteria

* No patient complaints
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Affiliated Hospital of North Sichuan Medical College

OTHER

Sponsor Role collaborator

North Sichuan Medical College

OTHER

Sponsor Role lead

Responsible Party

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Zining Luo

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, China

Site Status

Countries

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China

Other Identifiers

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2765326471-2024-1

Identifier Type: -

Identifier Source: org_study_id

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