Periodization and Parkinson's Disease

NCT ID: NCT07141849

Last Updated: 2025-09-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-29

Study Completion Date

2025-12-30

Brief Summary

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This study will compare the effects of high-speed power resistance training to periodized training, which includes cycle of hypertrophy, strength and power, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Detailed Description

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Conditions

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Activity, Motor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Power Resistance Training

Participants will receive high-speed power resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Group Type ACTIVE_COMPARATOR

Power Resistance Training

Intervention Type BEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include six upper-body exercises and five lower-body exercises.

Periodized Resistance Training

Participants will receive periodized resistance training twice per week for at least 24 weeks.

Group Type EXPERIMENTAL

Periodized Resistance Training

Intervention Type BEHAVIORAL

Participants will receive three weeks of hypertrophy training to increase muscle size followed by six weeks of strength training, and then three weeks of power training twice per week for a total of twenty-four 45-minutes in-person training sessions. During training participants will be allowed 1-minute rests between sets. Exercises will include six upper-body exercises and five lower-body exercises.

Interventions

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Power Resistance Training

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include six upper-body exercises and five lower-body exercises.

Intervention Type BEHAVIORAL

Periodized Resistance Training

Participants will receive three weeks of hypertrophy training to increase muscle size followed by six weeks of strength training, and then three weeks of power training twice per week for a total of twenty-four 45-minutes in-person training sessions. During training participants will be allowed 1-minute rests between sets. Exercises will include six upper-body exercises and five lower-body exercises.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Parkinson's Disease Hoehn \& Yahr Stages 1-3
* Able to walk 50m unassisted
* Able to understand and communicate in English

Exclusion Criteria

* Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
* Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
* Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
Minimum Eligible Age

50 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Joseph Signorile

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Joseph F. Signorile, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

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Laboratory of Neuromuscular Research and Active Aging

Coral Gables, Florida, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Caleb P Calaway, BS

Role: CONTACT

5203702715

Joseph F. Signorile, PhD

Role: CONTACT

3052843105

Facility Contacts

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Joseph F Signorile, PhD

Role: primary

305-284-3105

Role: backup

Other Identifiers

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20250800

Identifier Type: -

Identifier Source: org_study_id

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