Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

NCT ID: NCT07141394

Last Updated: 2025-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

7908 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-10-01

Study Completion Date

2030-09-30

Brief Summary

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The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Up to 40% of Veterans exit HUD-VASH within two years of attaining housing; substance use disorders (SUDs) are one of the largest causes of returns to homelessness for HEVs. CARE-VASH QUERI proposes to implement and evaluate two evidence-based SUD services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in HUD-VASH.

Detailed Description

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The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) program provides subsidized, permanent housing and supports to Veterans experiencing homelessness. Substance use disorders (SUDs) are a common primary or contributing factor to negative exits from HUD-VASH. The Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) QUERI will implement two evidence-based practices (EBPs) for SUDs-Medications for Addiction Treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD)-in 12 HUD-VASH sites. We will use the Replicating Effective Programs (REP) implementation bundle to support EBP implementation at all 12 sites. Half the sites (n=6) will also receive 9 months of consumer engagement (REP+CE). In a type 3 hybrid trial, we will use mixed methods to examine the impacts of REP vs. REP+CE. Using our trial data, we will develop a budget impact analysis and implementation playbook for our program partners to spread and sustain MAT and CBT-SUD in HUD-VASH.

Conditions

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Homelessness Substance Use Disorder (SUD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Investigators are implementing two evidence-based Substance Use Disorder (SUD) services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in the Department of Housing and Urban Development-VA Supportive Housing Program (HUD-VASH).
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Replicating Effective Programs (REP)

A stakeholder-informed training and technical assistance implementation strategy

Group Type EXPERIMENTAL

Medication for Addiction Treatment (MAT)

Intervention Type DRUG

MAT includes medications for alcohol use disorder (MAUD) and medications for opioid use disorder (MAUD). It reduces substance use, increases SUD treatment engagement, enhances quality of life, and reduces overdoses.

Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)

Intervention Type BEHAVIORAL

An evidence-based psychotherapy that uses cognitive behavioral therapy to further recovery goals across SUD diagnoses.

REP + Consumer Engagement (CE)

REP plus CE package (educational materials, peer coaching, toolkit) to support MAT and CBT-SUD implementation.

Group Type ACTIVE_COMPARATOR

Medication for Addiction Treatment (MAT)

Intervention Type DRUG

MAT includes medications for alcohol use disorder (MAUD) and medications for opioid use disorder (MAUD). It reduces substance use, increases SUD treatment engagement, enhances quality of life, and reduces overdoses.

Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)

Intervention Type BEHAVIORAL

An evidence-based psychotherapy that uses cognitive behavioral therapy to further recovery goals across SUD diagnoses.

Control Group

No MAT or CBT-SUD implementation

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Medication for Addiction Treatment (MAT)

MAT includes medications for alcohol use disorder (MAUD) and medications for opioid use disorder (MAUD). It reduces substance use, increases SUD treatment engagement, enhances quality of life, and reduces overdoses.

Intervention Type DRUG

Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)

An evidence-based psychotherapy that uses cognitive behavioral therapy to further recovery goals across SUD diagnoses.

Intervention Type BEHAVIORAL

Other Intervention Names

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MAT CBT-SUD

Eligibility Criteria

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Inclusion Criteria

* Homeless-experienced Veterans (HEVs) enrolled in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program.

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, Los Angeles

OTHER

Sponsor Role collaborator

VA Office of Research and Development

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sonya Emi Gabrielian, MD MPH

Role: PRINCIPAL_INVESTIGATOR

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Evelyn T Chang, MD MSHS

Role: PRINCIPAL_INVESTIGATOR

VA Greater Los Angeles Healthcare System, Sepulveda, CA

Erin P Finley, PhD MPH

Role: PRINCIPAL_INVESTIGATOR

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Emily Treichler, PhD

Role: PRINCIPAL_INVESTIGATOR

VA San Diego Healthcare System, San Diego, CA

Locations

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VA Greater Los Angeles Healthcare System, West Los Angeles, CA

West Los Angeles, California, United States

Site Status

Countries

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United States

Central Contacts

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Sonya E Gabrielian, MD MPH

Role: CONTACT

(310) 478-3711 ext. 49853

Jenny M Barnard, BA

Role: CONTACT

(626) 367-1077

Other Identifiers

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QUE 25-013

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

QUX 25-001

Identifier Type: -

Identifier Source: org_study_id

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