Effect of Acute Grape Seed Extract Supplementation on the Heart Rate Recovery in Young Individuals

NCT ID: NCT07137988

Last Updated: 2025-08-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-10-03
• Study Completion Date: 2024-12-31

Brief Summary

This study hypothesized that sustained sympathoexcitation via MMA slows down PHRR and that GSE supplementation is effective at improving PHRR in young individuals. 12 Participants were randomly assigned, via a double-blind, cross-over design, to either receive GSE (300mg, 2 capsules) or PL (300mg, 2 capsules), with a washout period of at least 72 hrs. between trials. A submaximal exercise test was performed using a cycle ergometer combined with isometric handgrip exercise using a handgrip dynamometer, and blood flow occlusion by placing a cuff over the brachial artery of the dominant arm. Post heart rate recovery (PHRR) was measured at 5 sec. intervals throughout the experiment. The PHRR was evaluated between GSE and PL at every min. for 300 sec.

Conditions

Healthy Young Men

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Experimental: Heart rate recovery with grape seed extract

Grape seed extract: 300 mg, two capsules Starch: 300 mg, two capsules

Group Type: EXPERIMENTAL

600 mg grape seed extract

Intervention Type: DIETARY_SUPPLEMENT

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

600 mg Starch

Intervention Type: DIETARY_SUPPLEMENT

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Sham Comparator: Experimental: BFR exercise without histamine blockade

Heart rate recovery with placebo (starch, 300 mg, 2 capsules)

Group Type: PLACEBO_COMPARATOR

600 mg grape seed extract

Intervention Type: DIETARY_SUPPLEMENT

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

600 mg Starch

Intervention Type: DIETARY_SUPPLEMENT

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Interventions

600 mg grape seed extract

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Intervention Type: DIETARY_SUPPLEMENT

600 mg Starch

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

600 mg starch

Eligibility Criteria

Inclusion Criteria

• good health, nonsmokers, those not taking medications that could affect cardiovascular function

Exclusion Criteria

• hypertension, muscular skeletal disorders

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

California Baptist University

OTHER

Sponsor Role: lead

Responsible Party

Jong-Kyung Kim

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

California Baptist University

Riverside, California, United States

Countries

United States

Other Identifiers

034-2425-EXP

Identifier Type: -

Identifier Source: org_study_id