Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest

NCT ID: NCT04389060

Last Updated: 2020-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-01

Study Completion Date

2020-03-01

Brief Summary

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This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction

Detailed Description

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Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.

Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators
Double blind, cross-over design

Study Groups

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GSE group

Subjects took a single dose of 600 mg GSE in capsule form through ingestion 2 hours prior to testing

Group Type ACTIVE_COMPARATOR

Grape seed extract

Intervention Type DIETARY_SUPPLEMENT

Two capsule grape seed extract (total 600 mg)

Placebo group

Subjects took a single dose of 600 mg starch in capsule form through ingestion 2 hours prior to testing

Group Type PLACEBO_COMPARATOR

Grape seed extract

Intervention Type DIETARY_SUPPLEMENT

Two capsule grape seed extract (total 600 mg)

Interventions

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Grape seed extract

Two capsule grape seed extract (total 600 mg)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Obesity: body mass index (\>30), Normal body weight: body mass index (25-29)

Exclusion Criteria

* cardiovascular diseases or consume any antihypertensive medication or supplementation that can affect blood pressure or aortic stiffness
Minimum Eligible Age

18 Years

Maximum Eligible Age

29 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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California Baptist University

OTHER

Sponsor Role lead

Responsible Party

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Jong-Kyung Kim

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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California Baptist University

Riverside, California, United States

Site Status

Countries

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United States

Other Identifiers

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081-1819-EXP

Identifier Type: -

Identifier Source: org_study_id

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